‘Genetic doppelgangers:’ Emory research provides insight into two neurological puzzles

An international team led by Emory scientists has gained insight into the pathological mechanisms behind two devastating neurodegenerative diseases. The scientists compared the most common inherited form of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) with a rarer disease called spinocerebellar ataxia type 36 (SCA 36). Both of the diseases are caused by abnormally expanded and strikingly similar DNA repeats. However, ALS progresses quickly, typically killing patients within a year or two, while the disease Read more

Emory launches study on COVID-19 immune responses

Emory University researchers are taking part in a multi-site study across the United States to track the immune responses of people hospitalized with COVID-19 that will help inform how the disease progresses and potentially identify new ways to treat it.  The study is funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The study – called Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) – launched Friday. Read more

Marcus Lab researchers make key cancer discovery

A new discovery by Emory researchers in certain lung cancer patients could help improve patient outcomes before the cancer metastasizes. The researchers in the renowned Marcus Laboratory identified that highly invasive leader cells have a specific cluster of mutations that are also found in non-small cell lung cancer patients. Leader cells play a dominant role in tumor progression, and the researchers discovered that patients with the mutations experienced poorer survival rates. The findings mark the first Read more

Global Health Institute

Exercise, changes in diet alter course for pre-diabetics

The D-CLIP Study staff in Chennai, India

A type 2 diabetes intervention program developed by researchers from Emory and the Madras Diabetes Research Foundation (MDRF) in India is showing promising results in improving risk factors, such as lowering weight and decreasing blood pressure and glucose levels.

The ongoing study, called the Diabetes Community Life Improvement Program, (D-CLIP) was designed to test the benefits of a low-cost community program for people at increased risk for type 2 diabetes, most commonly associated with obesity. The curriculum integrates exercise, nutrition education and dietary changes. The study is being conducted in Chennai, India with hopes of expanding the program into other parts of South Asia.

Six-hundred participants with prediabetes were randomly assigned to either a standard of care control treatment or weekly D-CLIP classes for six months, where they learned about making healthy choices in real life situations such as restaurants and grocery stores. They also learned how to incorporate exercise into their daily routines with the goal of completing 150 minutes of physical activity a week.

Of the 200 participants who have completed the course to date, 83 percent have lost between five and 13 pounds. There also was improvement in blood glucose, serum cholesterol and blood pressure levels in participants.

“This initial research is quite encouraging because it shows we can turn the tide of type 2 diabetes onset by promoting simple lifestyle changes through well-structured community programming,” says Venkat Narayan, MD, Hubert Professor in Emory’s Rollins School of Public Health and a professor in Emory School of Medicine. “Attendance at the lifestyle classes is 85 to 90 percent, with lifestyle changes strongly evident. More than anything, we have formed strong partnerships with the local community that will ultimately lead to the implementation of more successful programs like this.”

The study is conducted by the Global Diabetes Research Center, a collaboration between Emory University and MDRF in Chennai, India. The center received its initial support from the Emory Global Health Institute, with funding from BRiDGES (Bringing Research in Diabetes to Global Environments and Systems), an International Diabetes Federation program supported by an educational grant from Eli Lily. Currently, the 17th session of D-CLIP classes is in progress, with the study set to close in early 2013.

Participants in the D-CLIP study learned to incorporate exercise into their lives to stave off type 2 diabetes.

“We have always known that the right diet and exercise can improve health,” says V. Mohan, MD, president of the Madras Diabetes Research Foundation. “But there has been no scientific community-based program to quantify this until now. We hope this is just the beginning of efforts to reduce the incidence of the type 2 diabetes epidemic worldwide.”

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March madness: National global health case competition features 13 universities

March Madness of a different flavor overtook Emory University March 18-19 as more than 200 students, judges, observers and staff convened for the first national Emory Global Health Case Competition.

The competition involved 20 teams of five students each, representing at least three academic disciplines per team. Emory fielded eight teams, and 12 teams came from leading universities across the country: Dartmouth, Princeton, Penn, Cornell, Yeshiva, Duke, Vanderbilt, UAB, USC, UCSF, Rice, and Texas A&M. All these universities are members of the Consortium of Universities for Global Health.

The first-place team, from Emory (l-r): Jason Myers, Candler School of Theology; Abdul Wahab Shaikh, Goizueta Business School; Stephanie Stawicki, Laney Graduate School; Andrew K. Stein, Goizueta Business School; Jenna Blumenthal, Laney Graduate School; Krista Bauer (judge), GE director of global programs; Meridith Mikulich, School of Nursing (not pictured)

As in two past local and regional case competitions, this year’s event was student initiated, developed, planned, staffed and conducted.

This year’s signature sponsor was GE, with additional sponsorship from Douglas and Barbara Engmann, and internal Emory funding.

“Global health continues to grow as a primary interest of students at universities across the United States, and the Emory Global Health Case Competition has gained a reputation as the leading national team event to showcase the creativity, passion, and intellect of our future leaders in global health,” says Jeffrey Koplan, MD, MPH, director of the Emory Global Health Institute.

The Feb. 17, 2011 issue of The Lancet included an article by Koplan and Mohammed K. Ali, assistant professor of global health at Rollins School of Public Health on the benefits of problem-based competitions to promote global health in universities.

Teams worked through the night on Friday for their Saturday morning presentations. The case involved a proposal for improving conditions in several East African refugee camps in the face of a severe budget cut. Judges were blinded to the academic affiliations of the teams, but Emory won the top two prizes (first prize was $5,000). UCSF and Dartmouth received honorable mentions, and Rice was given an innovation award.

 

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Hong Kong is Bright Spot of Tobacco Control in China

Jeffrey Koplan, MD, MPH

A remarkably successful 20-year program of tobacco control in Hong Kong can serve as a best-practices example for China and other nations, says Jeffrey Koplan in an article published online today in The Lancet. Koplan is vice president for global health at Emory and director of the Emory Global Health Institute.

Hong Kong’s successful tobacco control program began with a 1982 health ordinance launching a multi-step approach including legislative amendments (regulation of indoor smoking, pack warnings, ban on tobacco advertising), a steeply increased tobacco tax, school-based education, mass-media campaigns, community events, and leadership from the medical community.

Smoking prevalence in Hong Kong fell from 23.3 percent in 1982 to 11.8 percent in 2008 through the efforts of the Tobacco Control office of the Department of Health and NGOs such as the Hong Kong Council on Smoking and Health.

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