A lot is happening in the Huntington’s disease (HD) field right now. Emory research reports on a pig HD model and on CRISPR/Cas9 gene editing are just part of the wave.
Let’s step back and review the technologies now available to treat this neurodegenerative disease, caused by a gene producing a toxic protein. Antisense approaches, under development for decades and now in clinical trials, shut off the problematic gene. However, this type of treatment would need to be regularly delivered to nervous system tissues. Gene editing — not in the clinic yet — could actually remove the gene from somatic cells in affected individuals.
Emory researchers developed the pig HD model in collaboration with colleagues in Guangzhou, and anticipate it will be a practical way to test treatments such as gene editing. In comparison with mice, delivery to affected nervous system tissues can be better tested in pigs, because their size is closer to that of humans. The pig model of HD, published yesterday in Cell, also more closely matches the symptoms of the human disease. This research was covered by Chinese media organizations.
Jeffrey Koplan, MD, MPH
Jeffrey Koplan, MD, MPH, director of the Emory Global Health Institute and vice president for Global Health at Emory University, is leading the second phase of the Tobacco Free Cities project in China, funded by the Bill and Melinda Gates Foundation. The project, which launched in 10 Chinese cities this week, is a partnership with the ThinkTank Research Center for Health Development in Beijing.
Vice mayors of each of the 10 cities signed an official pledge to strive to create tobacco-free cities for residents. China has more than 300 million smokers, the most of any country, and more than 500 million people in China are exposed to secondhand smoke.
â€œThe two-year project aims to enhance the overall capacity in smoking-tobacco control of the cities and help ease the burden caused by tobacco to public health, the environment and the economy,â€ Koplan says in an article in China Daily.
The project launch was covered by other major Chinese news outlets, including Xinhua News Agency.
The first phase of the Tobacco Free Cities project launched in June 2009 in seven Chinese cities. The project is part of the Emory Global Health Institute-China Tobacco Partnership. In January 2009 Emory University received a $14 million, five-year grant from the Gates Foundation to establish the partnership.
Posted on January 14, 2011
Peking University administrators with Georgia Tech, Emory delegation
A recent trip to Peking University (PKU) by administrators from Georgia Tech and Emory included a formal signing ceremony for the joint Georgia Tech/Emory/PKU PhD program in biomedical engineering. Georgia Tech President Bud Peterson and Tech Engineering Dean Don Giddens made the trip along with Larry McIntire, chair of the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory and Cheng Zhu, BME associate chair of international programs.
The joint PhD program was first announced last February and began enrolling its first students last fall. Students apply to the program through either the Department of Biomedical Engineering at PKU or the Coulter Department at Georgia Tech and Emory. Primary classes and research take place on the studentâ€™s home campus, but students spend at least a year in classes and research on the secondary campus.
Posted on May 25, 2010
Dr. Margaret Chan
On World TB Day, March 16, Dr. Margaret Chan, director-general of the World Health Organization, addressed public health professionals at the Centers for Disease Control and Prevention in Atlanta at the eighth annual Jeffrey P. Koplan Global Leadership in Public Health Lecture. In introducing Chan, Koplan noted their long-term friendship, which grew from their work together in China.
While in Atlanta, Chan also visited Emory to meet with President James Wagner and Emory Global Health Institute Director Koplan. She heard presentations about global health field projects by students in public health, medicine, and theology.
Chan recalled the â€œlost decade for development,â€ the 1980s, a dismal time for public health. The 1979 energy crisis followed by a recession made for tighter public health resources and few health care improvements worldwide, she explained. Some developing countries have still not recovered.
In contrast, public health has faired better in the new millennium, when the world has benefited from financial commitments backed by substantial resources, often from innovative sources, says Chan.
Posted on March 31, 2010
Jeffrey Koplan, MD, MPH
A remarkably successful 20-year program of tobacco control in Hong Kong can serve as a best-practices example for China and other nations, says Jeffrey Koplan in an article published online today in The Lancet. Koplan is vice president for global health at Emory and director of the Emory Global Health Institute.
Hong Kongâ€™s successful tobacco control program began with a 1982 health ordinance launching a multi-step approach including legislative amendments (regulation of indoor smoking, pack warnings, ban on tobacco advertising), a steeply increased tobacco tax, school-based education, mass-media campaigns, community events, and leadership from the medical community.
Smoking prevalence in Hong Kong fell from 23.3 percent in 1982 to 11.8 percent in 2008 through the efforts of the Tobacco Control office of the Department of Health and NGOs such as the Hong Kong Council on Smoking and Health.
Posted on March 26, 2010
Peking University in Beijing, China
The meteoritic rise of China in the world has seen a corresponding rise in the number of partnerships between Emory and Chinese universities and researchers.
In February 2009, Emory, Georgia Tech, and Peking University announced a joint biomedical engineering PhD program. Representatives from the schools have been laying the groundwork for this program during the past five years.Â In the Fall of 2009, members of the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University traveled to Beijing to finalize the program details with the Department of Biomedical Engineering at Peking University (PKU). Faculty collaborations have been funded by seed grants and, as a result, several new research projects are already underway.
Public health units at Emory are also reaching out to China. In February 2009, it was announced that Emory University has received a $14 million, five-year grant from The Bill & Melinda Gates Foundation to help reduce the burden of tobacco use in China. The Emory Global Health Institute, in collaboration with the Tobacco Technical Assistance Consortium (TTAC) of Emory’s Rollins School of Public Health, will establish the Emory Global Health Institute — China Tobacco Partnership.
China is likewise reaching out to Emory. According to the international business news site Global Atlanta, delegates from Chinaâ€™s Shandong province recently came to Atlanta to meet with health care professionals, public health officials, educational institutions and legislators.The group visited the the Emory Spine Center, where they met with acupuncturists using traditional Chinese techniques alongside new therapies.
Posted on June 22, 2009