Warren symposium follows legacy of geneticist giant

If we want to understand how the brain creates memories, and how genetic disorders distort the brain’s machinery, then the fragile X gene is an ideal place to start. That’s why the Stephen T. Warren Memorial Symposium, taking place November 28-29 at Emory, will be a significant event for those interested in neuroscience and genetics. Stephen T. Warren, 1953-2021 Warren, the founding chair of Emory’s Department of Human Genetics, led an international team that discovered Read more

Mutations in V-ATPase proton pump implicated in epilepsy syndrome

Why and how disrupting V-ATPase function leads to epilepsy, researchers are just starting to figure Read more

Tracing the start of COVID-19 in GA

At a time when COVID-19 appears to be receding in much of Georgia, it’s worth revisiting the start of the pandemic in early 2020. Emory virologist Anne Piantadosi and colleagues have a paper in Viral Evolution on the earliest SARS-CoV-2 genetic sequences detected in Georgia. Analyzing relationships between those virus sequences and samples from other states and countries can give us an idea about where the first COVID-19 infections in Georgia came from. We can draw Read more
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Shonna McBride

Focus on antibiotic resistance at ASM Microbe 2018

We are excited that the ASM Microbe meeting will be at the Georgia World Congress Center from June 7 to June 11. If you are interested in antibiotic resistance, you can learn about how to detect it, how to (possibly) defeat it and how the bacteria fight back.

A host of Emory microbiologists are participating. In some cases, our scientists are presenting their unpublished data for discussion with their colleagues at other universities. Accordingly, we are not going to spill the beans on those results. However, please find below some examples of who’s talking and a bit of explanatory background. ASM Microbe abstracts are available online for posters, but not for some symposiums and plenary talks.

David Weiss lab — Klebsiella

Graduate student Jessie Wozniak is presenting her research on an isolate of Klebsiella that combines alarming properties. She will describe how the bacterial colonies behave (unappetizingly) like stretchy melted cheese in a “string test.”

June 9, 11 am to 1 pm, June 11, 11 am to 1 pm

Christine Dunham – toxin-antitoxin/persistence

Graduate student Sarah Anderson presenting her poster at ASM Microbe. She discussed a genetic connection between virulence switch and antibiotic resistance.

Dunham, a structural biologist, is giving a plenary talk June 11 on toxin-antitoxin pairs, which play a role in regulating bacterial persistence, a dormant state that facilitates antibiotic resistance. Two past papers from her lab.

Phil Rather lab – Acinetobacter baumannii

Rather’s lab recently published a Nature Microbiology paper on A. baumannii’s virulence/opacity switch. This type of bacteria is known for hospital-associated infections and for wound infections in military personnel. Poster talk by graduate student Sarah Anderson June 8. Read more

Posted on May 22, 2018 by Quinn Eastman in Uncategorized Leave a comment

C. difficile: its name says what it is

If you’re looking for an expert on the “notorious” bacterium Clostridium difficile, consider Emory microbiologist Shonna McBride.

C. difficile is a prominent threat to public health, causing potential fatal cases of diarrheal disease. C. difficile can take over in someone’s intestines after antibiotics clear away other bacteria, making it dangerous for vulnerable patients in health care facilities. Healthcare-associated infections caused by other types of bacteria such as MRSA have been declining, leaving C. difficile as the most common cause, according to recently released data from the CDC.

Shonna McBride, PhD

McBride’s work focuses on how C. difficile is able to resist antimicrobial peptides produced by our bodies that keep other varieties of bacteria in check.

A 2013 paper from her lab defines genes that control C. difficile’s process for sequestering these peptides. It appears that its ability to resist host antimicrobial peptides evolved out of a system for resisting weapons other bacteria use against each other.

Since C. difficile requires an oxygen-free environment to grow, studying it can be more difficult than other bacteria. The McBride lab has a recent “video article” in the Journal of Visualized Experiments explaining how to do so using specialized equipment.

McBride explains in a recent Microbe magazine cover article that C. difficile’s ability to form spores is connected to the threat it poses:

Without the ability to form spores, the strict anaerobe C. diffıcile would quickly die in the presence of atmospheric oxygen. However, the intrinsic resilience of these spores makes them diffıcult to eradicate, facilitating the spread of this pathogen to new hosts, particularly in health care settings where they withstand many of the most potent disinfectants.

Yet the process of sporulation is markedly different in C. difficile compared with other kinds of bacteria, she says in the review.

Posted on April 10, 2014 by Quinn Eastman in Uncategorized Leave a comment