Researchers at Emory studying lung transplantation have identified a marker of inflammation that may help predict primary graft dysfunction (PGD), an often fatal complication following a lung transplant.
Primary graft dysfunction after a lung transplant
The results are published in the American Journal of Transplantation. First author Andres Pelaez, a pulmonary medicine specialist at Emoryâ€™s McKelvey Lung Transplant Center, and postdoc Patrick Mitchell led the research team.
â€œDespite major advances in surgical techniques and clinical management, serious lung transplant complications are common and often untreatable,â€ Pelaez says. â€œPGD is a severe lung injury appearing just a few days after transplantation. Unfortunately, predicting which lung transplant recipients go on to develop PGD has been so far unsuccessful. Therefore, our research has been directed towards identifying predictive markers in the donor lungs prior to transplantation.â€
Jana MacLeod, MD
Drunk drivers have been known to walk away from auto wrecksâ€”but thatâ€™s unusual. In fact, the norm is this: those who drink before an accident of any kind, particularly a motor vehicle accident, have a much higher chance of being injured or dying than if they hadnâ€™t been drinking at all.
So, Jana MacLeod, MD, and her colleagues trained surgical interns to conductÂ brief interventions on patients with alcohol-related injuries. MacLeod is an associate professor of surgery, Emory University School of Medicine. She says brief interventions offer patients a way to talk about their alcohol use with their physician, and then make behavioral changes if they so choose.
MacLeod talks about the benefits of these interventions in an Emory Sound Science podcast.
â€œRecent studies have shown brief alcohol interventions with trauma patients who have a history of alcohol misuse successfully prevented future episodes of drunk driving,â€ says MacLeod. Whatâ€™s more, itâ€™s been shown a five-minute intervention reduces hazardous drinking patterns up to three years after injury and decreases recidivism.
Posted on February 9, 2010