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trauma

Epigenetic inheritance via sperm RNA

In 2013, Brian Dias (at Yerkes) and Kerry Ressler (now at Harvard) described a surprising example of epigenetic inheritance.

They found that a mouse, exposed to a smell in combination with stress, could transmit the resulting sensitivity to that smell to its offspring. At the time, there wasn’t a lot of information about mechanism.

Now other scientists have substantiated a proposal that micro RNA in playing a role in sperm. See this story (“Sperm RNAs transmit stress”) from Kate Yandell in The Scientist or this one from Rachel Zamzow at Spectrum, the Simons Foundation’s autism news site, for more. An added wrinkle is that this research shows that descendants of stress-exposed mice show a muted response to stress.

Note for Emory readers: Dias is scheduled to give a Frontiers in Neuroscience talk on Friday.

Posted on by Quinn Eastman in Neuro Leave a comment

Talkin’ about epigenetics

This intriguing research has received plenty of attention,  both when it was presented at the Society of Neuroscience meeting in the fall and then when the results were published in Nature Neuroscience.

The short summary is: researchers at Yerkes National Primate Research Center found that when a mouse learns to become afraid of a certain odor, his or her pups will be more Gafas Ray Ban Baratas sensitive to that odor, even though the pups have never encountered it. Both the parent mouse and pups have more space in the smell-processing part of their brains, called the olfactory bulb, devoted to the odor to which they are sensitive.

[Note: a feature on a similar phenomenon, transgenerational inheritance of the effects of chemical exposure, appeared in Science this week]

Somehow information about the parent’s experiences is being inherited. But how? Brian Dias and Kerry Ressler are now pursuing followup experiments to firmly establish what’s going on. They discuss their research in this video:

 

Posted on by Quinn Eastman in Neuro Leave a comment

Intervention: preventing trips to the trauma unit

Jana MacLeod, MD

Drunk drivers have been known to walk away from auto wrecks—but that’s unusual. In fact, the norm is this: those who drink before an accident of any kind, particularly a motor vehicle accident, have a much higher chance of being injured or dying than if they hadn’t been drinking at all.

So, Jana MacLeod, MD, and her colleagues trained surgical interns to conduct brief interventions on patients with alcohol-related injuries. MacLeod is an associate professor of surgery, Emory University School of Medicine. She says brief interventions offer patients a way to talk about their alcohol use with their physician, and then make behavioral changes if they so choose.

MacLeod talks about the benefits of these interventions in an Emory Sound Science podcast.

“Recent studies have shown brief alcohol interventions with trauma patients who have a history of alcohol misuse successfully prevented future episodes of drunk driving,” says MacLeod. What’s more, it’s been shown a five-minute intervention reduces hazardous drinking patterns up to three years after injury and decreases recidivism.

Read more

Posted on by Holly Korschun in Uncategorized 1 Comment

Emory and Grady

Grady Memorial Hospital

Grady Memorial Hospital

Every day Atlanta’s lead stories call attention to it: “Shot teen taken to Grady,” “Burn victim ambulanced to Grady,” “Accident victim stable at Grady”– Atlantans, Georgians, and even out of state residents taken to Grady Memorial Hospital in their hour of direst need. What many don’t know however, is that Grady, Atlanta’s public hospital, doesn’t only treat emergencies; Grady is recognized for programs for breast cancer, stroke, sickle cell anemia and more.

Something else many don’t know: “Grady doctors” are Emory or Morehouse doctors. All doctors at Grady are faculty or residents from Emory University School of Medicine or Morehouse School of Medicine. Emory physicians provide close to 85 percent of all physician patient care delivered at Grady. For Emory, this connection goes back to before the Civil War.

Posted on by Wendy Darling in Uncategorized Leave a comment

Translating research into life-saving

You or a loved one is suffering severe brain trauma in the wake of an accident. Imagine if doctors told you there was a treatment available that could up your chances of survival and even your chances at recovery. This isn’t just theoretical, because that’s an option some Emory patients have had, thanks to the availability of PROTECT, a progesterone-based treatment developed at Emory University and being administered by Emory trauma doctors.

Dr. Donald Stein, whose research led to the development of PROTECT, has just been honored by the Association for Psychological Science for his research and commitment to finding treatments and cures for traumatic brain injured patients.

Watch the video below to learn the real-life story of an accident victim who benefited from Stein’s work and the work of Emory’s doctors.

Posted on by Wendy Darling in Uncategorized Leave a comment