COVID-19 vaccine-generated antibodies last at least 6 months

How long does COVID-19 vaccine-generated immunity last? New laboratory results provide a partial answer to that question.

Antibodies generated by a currently available COVID-19 vaccine declined over time, but remained at high levels in 33 study participants 6 months after vaccination, according to data published Tuesday in the New England Journal of Medicine.

The results could begin to inform public health decisions about COVID-19 booster vaccinations and how frequently people should receive them. In older study participants, antiviral antibody activity tended to decay more rapidly than in those aged 18-55.

From Doria-Rose et al (2021). Note that neutralizing antibody activity was (on average) higher at day 209 than on day 29, when the second vaccine dose was administered. It takes two weeks for the immune system to kick into high gear after the second shot.

Emory Vaccine Center’s Mehul Suthar, co-lead author of the brief report, said that the “correlates of protection” are not yet known from COVID-19 vaccine studies – that is, what levels of antiviral antibodies are needed to fend off infection. Other forms of immunity, such as T cells, could be contributing to antiviral protection as well.

He cautioned that the decay in antibody activity over time – not surprising in itself – may combine with increased prevalence of emerging SARS-CoV-2 variants that may allow viruses to escape the immune system’s pressure.

“Still, these are encouraging results,” Suthar says. “We are seeing good antibody activity, measured three different ways, six months after vaccination. There are differences between age groups, which are consistent with what we know from other studies.”

The findings come from analysis of samples from the Moderna mRNA-1273 phase I clinical trial, which began last year. Reports of clinical outcomes from Pfizer/BioNTech also indicate that their vaccine remains effective after six months.

The co-first authors of the NEJM report are Suthar and Nicole Doria-Rose, PhD, chief of the Humoral Immunology Core at the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases. Suthar’s laboratory is also supported by NIAID. For more information on grant support, see this Emory News Center article.

The data in the NEJM report include three different measures of antibody activity: spike protein binding, pseudovirus neutralization assay and live virus neutralization assay. The last is considered more sensitive.

When neutralizing antibody activity was measured in people aged 71 and older, average levels fell more than six fold, from 900 two weeks after vaccination to 131 six months later. For comparison, neutralizing antibody activity in those aged 18 to 55 declined about a factor of three (from 1388 to 406).

For neutralizing antibodies, half-life estimates ranged from 173 to 202 days, using models that take antibodies’ natural decay into account, adding in partial replenishment by vaccine-induced plasma cells.

Posted on by Quinn Eastman in Immunology Leave a comment

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Quinn Eastman

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