Genomics plus human intelligence

The power of gene sequencing to solve puzzles when combined with human Read more

'Master key' microRNA has links to both ASD and schizophrenia

Recent studies of complex brain disorders such as schizophrenia and autism spectrum disorder (ASD) have identified a few "master keys," risk genes that sit at the center of a network of genes important for brain function. Researchers at Emory and the Chinese Academy of Sciences have created mice partially lacking one of those master keys, called MIR-137, and have used them to identify an angle on potential treatments for ASD. The results were published this Read more

Shape-shifting RNA regulates viral sensor

OAS senses double-stranded RNA: the form that viral genetic material often takes. Its regulator is also Read more

Ophthalmology

Optic nerve reaching out

Congratulations to Ying Li, MD, PhD, 3rd place winner of the Best Image contest held as part of the Emory Postdoctoral Research Symposium, which takes place next week (Thursday, May 19). Li is in Eldon Geisert’s lab, and provided Lab Land this description:

“Like a benevolent overseer of the cosmos, the epicenter of the optic nerve appears to extend a axon reassuringly to the small, seemingly lowly single ganglion cell, reminding us that every cell matters.”i-6FBNVsV-X3

Posted on by Quinn Eastman in Neuro Leave a comment

Seeing leaves on trees

Was your mother right when she told you not to read in dim light? Is there a correlation between your love of reading as a child and the fact that you now need glasses for distant objects?

These questions and more are being addressed by researchers at Emory and the Veterans Administration.

In a lab at the Atlanta Veterans Affairs Medical Center near Emory, researcher Machelle Pardue, PhD, who has an appointment at Emory Eye Center, studies why some eyes seem to change over time, growing larger and longer, thereby making that eye what we call “nearsighted.” This dependence on glasses or contact lenses to see distant objects seems to be a growing phenomenon. Scientists and ophthalmologists call this nearsightedness myopia, and whether it’s environmental or genetic—or a likely combination of both—is fascinating to Pardue and her research colleagues.

Michelle Pardue, PhD

The unique collaborative nature of Pardue’s work draws on the talents of many specialists—clinical, engineering, molecular, and imaging. Her ongoing work and the work of others who serve both at the VA and Emory will no doubt lead to important findings and from that, possible clinical treatments.

For more information about Pardue’s work, read the feature article  “Closing in on myopia—and more” in Emory Eye magazine, summer 2010, page 8.

Posted on by Joy Bell in Uncategorized Leave a comment

Finding success in retinoblastoma treatment

The idea of your child having an eye removed is shocking, an extremely difficult thing for a parent to cope with, says Baker Hubbard, MD, Thomas M. Aaberg Professor of Ophthalmology, and a pediatric ocular oncologist. Actually, says Hubbard, most children who lose an eye adapt very well and enjoy essentially normal lives.

Baker Hubbard, MD

Retinoblastoma is cancer that forms in the tissues of the retina (the light-sensitive layers of nerve tissue at the back of the eye). Retinoblastoma usually occurs in children younger than age five. It may be hereditary or nonhereditary (sporadic), and is caused by mutations in genes.

To six-year-old Emilia McKibbin, having a prosthetic eye is no big deal. She knows to protect it—wearing her glasses for school and playtime, donning a scuba mask at the beach—but it doesn’t limit her choices.

Following her interests, Emilia has earned a gold belt in karate. She’s learning gymnastics. She swims. She loves to romp with Daisy, her black cocker spaniel. And while most people don’t even notice that one of this little girl’s shining dark-brown eyes is different from the other, Emilia shares her story with a few. “I tell my teachers and my friends that I have a special eye,” she says.

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Posted on by Joy Bell in Uncategorized 3 Comments