Precision medicine with multiple myeloma

“Precision medicine” is an anti-cancer treatment strategy in which doctors use genetic or other tests to identify vulnerabilities in an individual’s cancer subtype. Winship Cancer Institute researchers have been figuring out how to apply this strategy to multiple myeloma, with respect to one promising drug called venetoclax, in a way that can benefit the most patients. Known commercially as Venclexta, venetoclax is already FDA-approved for some forms of leukemia and lymphoma. Researchers had observed that multiple Read more

Promiscuous protein droplets regulate immune gene activity

Biochemists at Emory are achieving insights into how an important regulator of the immune system switches its function, based on its orientation and local environment. New research demonstrates that the glucocorticoid receptor (or GR) forms droplets or “condensates” that change form, depending on its available partners. The inside of a cell is like a crowded nightclub or party, with enzymes and other proteins searching out prospective partners. The GR is particularly well-connected and promiscuous, and Read more

Neutrophils flood lungs in severe COVID-19

In the lungs of severe COVID-19 patients, neutrophils camp out and release inflammatory cytokines and tissue-damaging Read more

oil disaster

Gulf residents and workers face heat exhaustion, mental stress

Residents and relief workers along the oil-ravaged Gulf of Mexico could experience a host of short- and long-term health problems, including respiratory ailments, neurological symptoms, heat exhaustion and mental stress.

Emory University environmental health expert Linda McCauley, RN, PhD, is one of more than a dozen national scientists participating in a two-day Institute of Medicine (IOM) workshop in New Orleans exploring some of the potential health risks that people in the Gulf could face.

Short term, McCauley says, there could be reports of respiratory problems from people who’ve inhaled gas fumes as well as neurological issues such as dizziness, headaches, nausea and vomiting. In addition, exposure to oil may cause eye and skin irritation.

Heat stress is also a major concern for workers in the Gulf, says McCauley, dean of Emory’s Nell Hodgson Woodruff School of Nursing.

“On some of the days it’s been so hot they’ve only allowed workers to work 12 minutes out of the hour,” she says. “A lot of new workers are being brought in [to clean up the oil]. These are workers who don’t do this for a living and may never have been exposed to this type of heat before and that’s a serious issue.”

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