Cancer biologists Jessica Konen and Scott Wilkinson,Â in Adam Marcus’ lab, recently published a paper on the function of LKB1, a gene that is often mutated in lung cancer cells. [Number three behind K-ras and p53.]
Konen and Marcus were featured in a prize-winning video that our team produced last year, which discusses how they developed a technique for isolatingÂ “leader cells”Â — lung cancer cells that migrate and invade more quickly — from a large groupÂ and studying those cells’ properties more intensively.
TheÂ Molecular Biology of the Cell paper covers a related topic: how LKB1 mutation affects cell shape. In particular, losing LKB1 converts lung cancer cells from a “mesenchymal” morphology to an “amoeboid” morphology.Â Read more