Search Results for: antibiotic resistance

Focus on antibiotic resistance at ASM Microbe 2018

May 22nd, 2018 (No Comments)

Host of Emory microbiologists participating.

Adaptive mutation mechanism may drive some forms of antibiotic resistance

August 27th, 2015 (No Comments)

Retromutagenesis resolves the puzzle: if cells aren’t growing because they’re under stress, which means their DNA isn’t being copied, how do the new mutants appear?
The answer: a mutation appears in the RNA first. Despite its name, retromutagenesis does not involve reverse transcriptase.

Antibiotic resistance enzyme caught in the act

July 30th, 2014 (1 Comment)

ICYMI, part of an increasing interest in antibiotic resistance at Emory, coming from many angles: biochemistry/microbiology/infectious diseases.

“Trojan horse” antibiotic underperforms; does heteroresistance explain?

April 26th, 2021 (No Comments)

A stealthy form of antibiotic resistance may be limiting the effectiveness of a new weapon against bacterial infections, research from Emory’s Antibiotic Resistance Center suggests. The antibiotic cefiderocol (Fetroja) was developed by the Japanese company Shionogi, and was FDA-approved for the treatment of complicated urinary tract infections in 2019 and for hospital-acquired bacterial pneumonia in […]

New antibiotic tactic vs gonorrhea

March 25th, 2021 (No Comments)

A new antibiotic compound can clear infection of multi-drug resistant gonorrhea in mice with a single oral dose, according to a new study led by researchers at Penn State and Emory.

Improve old antibiotics rather than discover new ones, BME researchers propose

September 10th, 2020 (1 Comment)

Lower doses of aminoglycosides could be used to treat bacteria when combined with specific metabolic sugars

Retaining the resistance: MCR-1, colistin + lysozyme

October 18th, 2016 (No Comments)

The plasmid MCR-1, which confers resistance to the last-resort antibiotic colistin, also confers resistance to an antimicrobial enzyme produced by our bodies. This suggests that the pressure of fighting the host immune system may select for MCR-1 to stick around, even in the absence of colistin use.

Fooling the test: antibiotic resistant bacteria that look susceptible

May 13th, 2016 (No Comments)

The phenomenon of heteroresistance could be causing unexplained treatment failures in the clinic and highlights the need for more sensitive diagnostic tests. Enterobacter cloacae from CDC image library.

Rescuing existing antibiotics with adjuvants

January 15th, 2016 (No Comments)

Many of the points Gerald Wright made at Thursday’s Antibiotic Resistance Center Symposium on combination drug discovery strategy could apply to approaches taken by Emory researcher Cassandra Quave.

Nudging physician behavior on antibiotic orders

November 3rd, 2015 (1 Comment)

Give doctors a subtle push in terms of antibiotic cost information, and they appear to respond.