Focus on antibiotic resistance at ASM Microbe 2018
Host of Emory microbiologists participating.
Adaptive mutation mechanism may drive some forms of antibiotic resistance
Retromutagenesis resolves the puzzle: if cells arenâ€™t growing because theyâ€™re under stress, which means their DNA isnâ€™t being copied, how do the new mutants appear?
The answer: a mutation appears in the RNA first. Despite its name, retromutagenesis does not involve reverse transcriptase.
Antibiotic resistance enzyme caught in the act
ICYMI, part of an increasing interest in antibiotic resistance at Emory, coming from many angles: biochemistry/microbiology/infectious diseases.
“Trojan horse” antibiotic underperforms; does heteroresistance explain?
A stealthy form of antibiotic resistance may be limiting the effectiveness of a new weapon against bacterial infections, research from Emory’s Antibiotic Resistance Center suggests. The antibiotic cefiderocol (Fetroja) was developed by the Japanese company Shionogi, and was FDA-approved for the treatment of complicated urinary tract infections in 2019 and for hospital-acquired bacterial pneumonia in […]
New antibiotic tactic vs gonorrhea
A new antibiotic compound can clear infection of multi-drug resistant gonorrhea in mice with a single oral dose, according to a new study led by researchers at Penn State and Emory.
Improve old antibiotics rather than discover new ones, BME researchers propose
Lower doses of aminoglycosides could be used to treat bacteria when combined with specific metabolic sugars
Retaining the resistance: MCR-1, colistin + lysozyme
The plasmid MCR-1, which confers resistance to the last-resort antibiotic colistin, also confers resistance to an antimicrobial enzyme produced by our bodies. This suggests that the pressure of fighting the host immune system may select for MCR-1 to stick around, even in the absence of colistin use.
Fooling the test: antibiotic resistant bacteria that look susceptible
The phenomenon of heteroresistance could be causing unexplained treatment failures in the clinic and highlights the need for more sensitive diagnostic tests. Enterobacter cloacae from CDC image library.
Rescuing existing antibiotics with adjuvants
Many of the points Gerald Wright made at Thursday’s Antibiotic Resistance Center Symposium on combination drug discovery strategy could apply to approaches taken by Emory researcher Cassandra Quave.
Nudging physician behavior on antibiotic orders
Give doctors a subtle push in terms of antibiotic cost information, and they appear to respond.