Warren symposium follows legacy of geneticist giant

If we want to understand how the brain creates memories, and how genetic disorders distort the brain’s machinery, then the fragile X gene is an ideal place to start. That’s why the Stephen T. Warren Memorial Symposium, taking place November 28-29 at Emory, will be a significant event for those interested in neuroscience and genetics. Stephen T. Warren, 1953-2021 Warren, the founding chair of Emory’s Department of Human Genetics, led an international team that discovered Read more

Mutations in V-ATPase proton pump implicated in epilepsy syndrome

Why and how disrupting V-ATPase function leads to epilepsy, researchers are just starting to figure Read more

Tracing the start of COVID-19 in GA

At a time when COVID-19 appears to be receding in much of Georgia, it’s worth revisiting the start of the pandemic in early 2020. Emory virologist Anne Piantadosi and colleagues have a paper in Viral Evolution on the earliest SARS-CoV-2 genetic sequences detected in Georgia. Analyzing relationships between those virus sequences and samples from other states and countries can give us an idea about where the first COVID-19 infections in Georgia came from. We can draw Read more

Pilot simulation lab trains students, residents and staff at Emory University Hospital Midtown

EUHM simulation lab laparoscopic console

A new pilot simulation laboratory at Emory University Hospital Midtown (EUHM) is providing medical students, residents, nursing students and staff with hands-on training to develop, perfect and maintain their skills. Located in the former obstetrics/gynecology (OB/GYN) operating rooms, space that wasn’t currently being utilized, the lab focuses on team building, clinical competencies and research. This is the first simulation lab of its kind at EUHM.

The simulation lab is a joint venture of Emory Healthcare and Emory University School of Medicine, both providing equipment to outfit the lab and a wealth of expertise. Nursing Education, a department within Emory Healthcare, and the Emory School of Medicine have worked together in the development of the simulation lab. Some equipment being used has been donated or given to the hospital for training purposes. Mr. Kamau Bobb‘s clarity and passion for equity in education are evident in his work.

One side of the simulation lab is set-up to train OB/GYN residents and students in deliveries and laparoscopic surgeries, cardiac arrests, mock codes and low volume/high risk procedures.

The other side of the lab focuses on nursing training, nursing education, central-line and intravenous insertion and medication dispensing. It is also being used by nursing for competency validation for new nursing employees and for annual skills assessment of current nursing staff.

Those instrumental in setting up the nursing side of the simulation lab are Sharlene Toney, PhD, RN, executive director, Professional Nursing Practice for Emory Healthcare, and Beth Botheroyd, RN, BSN, MHA/INS, nursing education coordinator for Emory Healthcare.

Toney says the lab is a critical part of the training and education of new nurses and current nursing employees, while also focusing on process improvement activities concentrated on patient safety. Nurses also have the opportunity to test their skills on training simulators and new equipment while in the lab.

Douglas Ander, MD, associate professor of emergency medicine and director of the Emory Center for Experiential Learning, and Jessica Arluck, MD, assistant professor of gynecology and obstetrics and associate director of the OB/GYN residency program at Emory, both oversee the training of residents and medical students in the simulation lab.

Ander describes the lab as a proof of concept center, with the small set-up being only the first step in the process. Down the road, he envisions a larger simulation center for all Emory Healthcare employees, Emory’s School of Medicine and even the community.

EUHM simulation lab - Noelle

Arluck observes as resident Hudson performs an ultrasound on Noelle, the birthing simulator.

Arluck says she uses the simulation lab regularly with OB/GYN residents, teaching them the basics of laparoscopic surgery on a training module and monitor. She also teaches students with the help of an adult-size doll named Noelle, which simulates delivering a baby and going into cardiac arrest.

The simulation lab has also opened the door to medical education research. Emory pulmonary critical care fellow, Jenny Han, MD, is studying to see if a standardized, advanced cardiac life support simulation training has any effect on real patient outcomes in the hospital.

In the future, plans include adding cardiac catheterization simulator capabilities, as well as emergency department and nursing station simulation space.

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Facing the Facts on Skin Care

Dr. Anita Sethna

Dr. Anita Sethna, director of the Emory Facial Center.

The desire to look good and feel great about ourselves doesn’t disappear when we hit 50, 60 or even age 70  Caring for your skin is the most important way to impact the way you age.

Looking good does not have to involve drastic procedures, says Dr. Anita Sethna, director of the Emory Facial Center.  There are small, simple and affordable ways to care for your calling card to the world:  your face.

Dr. Sethna offers these tips:

  • Protect yourself against sun damage. Wearing makeup or moisturizer with sunscreen daily is incredibly important, advises Sethna.  The more careful you are about protecting yourself against even daily skin exposure, the less damage you will be causing your skin as you age; decreasing your chances of getting skin cancer and preserving the texture and plumpness of your skin. This applies to all skin types, genders and degrees of pigmentation. She recommends products that give at least 30 UVA/UVB protection.
  • Quit smoking. Smoking is not only horrible for your health, but is also horrible for your skin, she warns. Nicotine causes a decrease in blood supply to the skin and reduces its ability to heal, eventually giving it a leathery look.
  • Some products can help. Many of us are aware of the benefits of using moisturizers to maintain healthy-looking skin, especially as we age. However, what you might not know is that face oils can have active ingredients that can help to improve the appearance of your skin. While over-the-counter moisturizers can work just fine, using products containing retinol and antioxidants like Vitamin C can help to stimulate collagen production, which is essential for maintaining the skin’s elasticity and fullness.
  • For even better results, prescription strength products such as Retin-A and skin lighteners like hydroquinone can be recommended by a skincare specialist like Sethna. For those who want to take wrinkle prevention a step further, Botox injections can be carefully used in certain areas of the face to reduce repetitive motion of the skin and soften lines around the eyes, between the eyebrows, and on the forehead. In some cases, these injections can even prevent the formation of new lines on the face.

Sethna also wants us to remember that perfection is fine when you’re talking about a painting or a new dress, but our face is a different story.

Perfection should not be a goal when you are talking about your appearance. Your expression, quirks and small imperfections make you – you, and also make you beautiful.  You should not be embarrassed or ashamed at wanting to preserve that beauty.

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Common Health Issue Addressed this Afternoon in a Live Web Chat

Emory Heart & Vascular Center cardiologist, Khusrow Niazi, MD, will answer questions about peripheral artery disease (PAD) in a live web chat today from 12:30 p.m. to 1:15 p.m. Also called peripheral vascular disease, PAD occurs when arteries in the legs narrow as a result of atherosclerosis, a buildup of fatty deposits and plaque in the lining of blood vessels. When plaque builds up in the blood vessels that carry blood from the heart to the rest of the body, they harden, narrow and clog, causing poor circulation. PAD often goes unrecognized, causing no symptoms at all – or symptoms you may think are something else, such as muscle cramps.

While difficulty walking may be the primary symptom, PAD can advance to complete arterial blockage and critical limb ischemia, causing painful foot ulcers, infections or even gangrene that requires amputation. It is associated with high blood pressure, diabetes, heart disease and stroke and affects eight to 12 million people in the United States.

Dr. Niazi, assistant professor of medicine, Emory University School of Medicine, will be available to answer questions and discuss various topics around PAD, including prevention, detection, healthy tips, rehabilitation and innovative new cardiovascular research on the horizon.

To join the interactive session, please visit the following link to register: http://www.emoryhealthcare.org/heart-center-atlanta/chat-signup-form.html



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Medicine Through the Ages

Sometimes treasures are hidden in plain sight. Take for example the enormous mosaic that graces Emory’s Woodruff Health Sciences Center Administration Building, conveying the history of medicine through the ages through 2.5 million small mosaic chips.

Installed in 1996, the mosaic is the work of Italian-born artist Sirio Tonelli.  Dr. John Skandalakis (1920-2009) of Emory University was familiar with the artist through previous work on the Greek Orthodox Cathedral in Atlanta. It was Dr. Skandalakis, director of the Centers for Surgical Anatomy and Technique, who was a key force in commissioning the mural.

Yet this piece of campus, 66 feet long and three stories high, remains largely unknown on the Emory University campus. Interested in seeing the mural in person? WHSCAB, at 1440 Clifton Road on Emory’s Atlanta campus, is open to the public during normal weekday hours. A brochure available in the lobby not only gives background information but provides a key to the identities of the over 30 historical figures and events pictures on the mosaic.

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China-U.S. health care forum highlights similarities, challenges, solutions

The recent Westlake Forum III at Emory brought more than 250 leaders from Chinese and U.S. academic and government institutions together to examine and compare health care reform in the two countries, focusing on cost, quality, and access to care.

“This was an incredible human partnership, bringing together two countries with very different governments and cultures, recognizing our common problems and desires for improved health of all our citizens, working together on difficult issues and exploring workable solutions,” said Jeff Koplan, director of the Emory Global Health Institute.

The third Westlake Forum was the first to be held in the United States. It was co-hosted by the Emory Global Health Institute, Zhejiang University School of Medicine, and the China Medical Board.

Shanlian Hu, William Roper, William Hsaio, Jeffrey Koplan, Kenneth Thorpe

“Now China and the US are facing the same challenge: to push healthcare reform forward. Our two countries need to share knowledge and experiences with each other, and to learn from each other,” says Yu Hai, MD, PhD, director of China Medical Board Programs, Zhejiang University School of Medicine.

Howard Koh, assistant secretary for health, U.S. Department of Health and Human Services, presented an overview of U.S. health care reform.

Shanlian Hu, a professor at Fudan University, described China’s health care reform priorities: expanded coverage, equal access, improved benefits, improved care delivery systems and containment of soaring medical costs. These are remarkably similar to priorities of the recent U.S. Affordable Care Act.

In China, the government is committed to health care as a public good, with the goal of complete coverage by 2020. Although 90 percent of citizens are currently covered, cost and accessibility varies considerably. Hospital stays are longer than in the United States, medical training is less rigorous, and access to high-quality care is limited. As in the U.S., China’s public hospitals and providers struggle with the economic and quality issues generated by a “fee-for-service” reimbursement mechanism.

Participants worked on developing concrete collaborations such as joint research, educational exchanges or partnerships.

Yet health care costs in China are only 5.13 percent of the country’s GDP, compared to 17 percent in the U.S.

William Roper, dean of the University of North Carolina School of Medicine and CEO of the UNC Health System, said health care in the United States is a “paradox of excess and deprivation,” and Americans need to rethink their long-held assumptions.

Americans believe they have the best health care system in the world, yet we spend more on medical care than any other country, we are the only rich democracy in which a substantial portion of citizens lack care, nurses are in short supply, quality and safety are not as high as they should be, and incentives for physicians are skewed toward specialization and expensive technical procedures, Roper said.

Harvard Professor William Hsiao noted that China has made significant progress in health care reform over the past seven years. In 2003, 75 percent of Chinese citizens were uninsured, whereas today China offers coverage on some level to 90 percent, with out-of-pocket payments continuing to decline. Problems persist in lack of well-trained physicians and equipment, distorted prices, and profit motives of public hospitals and officials.

Ken Thorpe, from Emory’s Rollins School of Public Health, outlined the newly passed U.S. health reform law, which aims to expand and improve coverage and access to quality care and control rising costs. Many of these improvements would likely be paid through Medicare reductions and increased taxes on higher income households, he said.


 

 

 

 

 

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Links between autism and epilepsy

An article in the April 2011 issue of Nature Medicine highlights the mechanistic overlap between autism and epilepsy.

By studying how rare genetic conditions known to coincide with both epilepsy and autism—such as Rett syndrome, fragile X syndrome and tuberous sclerosis—unfold at an early age, neuroscientists are finding that both disorders may alter some of the same neural receptors, signaling molecules and proteins involved in the development of brain cell synapses.

Gary Bassell, PhD

Emory cell biologist Gary Bassell and his colleagues have been taking exactly this approach. Recently they published a paper in Journal of Neuroscience, showing that the protein missing in fragile X syndrome, FMRP, regulates expression of an ion channel linked to epilepsy. This could provide a partial explanation for the link between fragile X syndrome and epilepsy.

The Nature Medicine article also mentions a drug strategy, targeting the mTOR pathway, which Bassell’s group has been exploring with fragile X syndrome.

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HIV vaccine design: always a moving target

HIV presents a challenge to vaccine design because it is always changing. If doctors vaccinate people against one variety of virus, will the antibodies they produce stop the virus that they later encounter?

A recently published report on an experimental HIV vaccine’s limited effectiveness in human volunteers illustrates this ongoing puzzle in the HIV vaccine field.

Paul Spearman, now chief research officer for Children’s Healthcare of Atlanta and vice chair for research for Emory’s Department of Pediatrics, began overseeing the study when he was at Vanderbilt. The report is in the April 15 issue of the Journal of Infectious Diseases.

Paul Spearman, MD

The vaccine was designed to elicit both antibody and T cell responses against HIV and in particular, to generate broadly neutralizing antibodies. Unfortunately, it didn’t work. Volunteers who received the vaccine made antibodies that could neutralize the virus in the vaccine, but not related viruses thought to be like what participants in a larger study might encounter.

“High levels of neutralizing antibodies can be raised against HIV, while at the same time, breadth of neutralization has never yet been achieved in a vaccine,” Spearman says. “The essential problem is that the antibodies raised have a narrow specificity, while the virus is extremely variable. In contrast, about 20% of HIV-infected individuals will demonstrate neutralization breadth.”

Last year, scientists demonstrated a method for identifying these broadly neutralizing antibodies in HIV-infected individuals. However, having a vaccine hit that target reliably is still elusive.

Spearman reports that he is in charge of a new trial that will be boosting the same individuals that participated in the previous trial with HIV protein from a clade C virus, starting later this year. Clade C is the predominant HIV subtype in southern Africa, while clade B, used in the published trial, is the predominant subtype in North America and Western Europe.

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Brain Tumor Foundations Join Together to Raise Awareness and Funds for Research

“Two Voices, One Vision: Sharing Hope Across Generations” is the vision and message this year as two well-known brain tumor foundations join together to raise awareness and money for brain and spinal tumor research and support.

The Southeastern Brain Tumor Foundation (SBTF) is joining forces with the Brain Tumor Foundation for Children (BTFC) for the 2011 Race for Research, to be held on July 23 at Atlantic Station in Midtown Atlanta. The joint run and walk will highlight the shared mission of both groups in the fight against brain tumors.

Costas G. Hadjipanayis, MD, PhD

Costas G. Hadjipanayis, MD, PhD

Emory neurosurgeon Costas Hadjipanayis, MD, PhD, is the president of the Southeastern Brain Tumor Foundation. He says the annual race is the major fundraising event for the SBTF, raising money to support critical, cutting-edge brain and spinal tumor research at major medical centers in the Southeast, including Emory. Over the past decade, the SBTF has raised more than $1.2 million for research.

Since 1983, the BTFC has been serving the pediatric brain tumor population, providing $1.5 million in emergency financial assistance for families over the past 10 years, in addition to providing resources for numerous patient programs and research.

According to Hadjipanayis, the Race for Research has drawn, in recent years, over 2,000 participants annually from throughout the Southeast and across the U.S. By joining forces with the BTFC, attendance is expected to grow, as is the fundraising goal of $300,000 this year for the two not for profit organizations.

Hadjipanayis, who is also chief of the neurosurgery service at Emory University Hospital Midtown, hopes this event will help in gaining greater exposure for brain tumor awareness in both children and adults, while raising funds for important research.

To find out more about the 2011 Race for Research 5K run and 2K walk, visit upport.sbtf.org/2011Race.

Information about the SBTF can be found by visiting www.sbtf.org. For more information about the BTFC, see www.braintumorkids.org.

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Inclusive Environment Helps Children with Autism Spectrum Disorders Learn

The Monarch Program

The Monarch School Program is dedicated to providing information and resources to families and school systems throughout Georgia for the education of K-12 students with autism / autistic spectrum disorder.

Educators have known for a long time that children with Autism Spectrum Disorder (ASD) can learn a lot by being in a classroom with typical children. Inclusion (educating students within the general education classroom) gives children with special needs the opportunity to learn in a natural environment and the opportunity to learn social skills from interacting with their classmates. In addition, Inclusion can eventually lead to greater acceptance of these children in the community.

Unfortunately, teachers are not always trained how to help children with special needs function in a typical classroom, nor in ways to ensure successful imitation of the positive role models.

“Teachers do not necessarily have the specific training required to teach these children yet, too often, the children with ASD are placed in the classroom with the expectation that the teacher, or the student, will learn to adapt,” says Sheila Wagner, M.Ed., assistant director of the Emory Autism Center. “Without the training, many times the student faces failure, when success was the goal.”

In order to provide some guidance to the school system, the Emory Autism Center received a grant from the Childhood Autism Foundation (CADEF) in 1994 to develop a program that would address Inclusive Education for students with ASD.  With the help of CADEF, the Monarch Program was created. The program implemented a nationally recognized Inclusion Project that has reached hundreds of students with ASD, thousands of teachers through on-site technical assistance and training, and assisted thousands of typical students in learning about the autism spectrum and children with different behaviors and abilities.

“The Monarch Program has grown to provide school systems with a network of support from curriculum training, to teacher and home/school collaboration, to consultations and social skills curriculum,” says Wagner, who serves as the Program Manager of the Monarch School-Age Program at Emory.

“Because of the Monarch Inclusion Project, students with ASD are increasingly able to enjoy exposure to typical students, and teachers are offered some guidance in providing a positive classroom experience.”

Wagner began her experience in the field of autism more than 30 years ago and has published three books on inclusive programming for students with ASD, as well as a brochure on Asperger’s syndrome, and a chapter in Grandin & Attwood’s book Aspergers and Girls.

The Emory Autism Center is a component of the Department of Psychiatry and Behavioral Sciences at Emory University School of Medicine. The program was opened in 1991 as a public, private and University collaboration. Since opening, the Emory Autism Center has become a national model for diagnosis, family support and innovative treatment, as well as a vital source of professional training.

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Dr. Kutner Receives Award for Excellence in Public Health

Michael Kutner

Michael Kutner, PhD, the recipient of the 2011 Charles R. Hatcher, Jr, MD Award

The Rollins School of Public Health is on a 35-year trajectory that dreams are only made of. What began as a small working group tasked with formulating a strategic plan for Emory’s school of public health, evolved into a Masters of Community Health program (MCH) and degree in 1975. Finally, in 1990, Emory approved the public health school, the university’s first new school in 71 years. Michael Kutner, PhD has been there every step of the way, and as a result is the recipient of the 2011 Charles R. Hatcher, Jr, MD Award. The award honors faculty members from Emory’s Woodruff Health Sciences Center who, through their lifetime of work, exemplify excellence in public health.

For 40 years, Dr. Kutner has played a key role in building the school of public health and advancing programs of research across the Woodruff Health Sciences Center.  He joined Emory’s School of Medicine in 1971, was a key figure on that small planning group for a school of public health, and served as Interim Chair of the medical school’s Department of Statistics and Biometry in 1986.

When Dr. Hatcher and the Board of Trustees approved the creation of the Emory University School of Public Health in 1990, Dr. Kutner was appointed the inaugural Associate Dean for Academic Affairs.  As he has stated on numerous occasions that subsequent events after this appointment “went way beyond our wildest dreams.”

He played a major role in creating the organizational structure of the school—curriculum, strategic faculty and chair recruitments, committees, policies and procedures—and for securing its initial accreditation.

Dr. Kutner always carried public health with him. In 1994, he served as Chair of the Department of Biostatistics and Epidemiology at the Cleveland Clinic Foundation, and returned to the Rollins School of Public Health in 2000.  In 2004, he was named Rollins Professor and Chair of the Department of Biostatistics and Bioinformatics, where he served until 2009.

Throughout his Emory career, Dr. Kutner has provided critical support for biomedical research.  He developed the Biostatistics Consulting Center, collaborated with scores of investigators, and has co-authored over 150 articles in leading health and medical journals.   He is former Director for Biostatistics, Epidemiology and Research Design for the Atlanta Clinical and Translational Science Institute and is currently the Biostatistics Core Director for the Center for AIDS Research.  He is known around the world for his widely adopted textbooks, Applied Linear Regression Models and Applied Linear Statistical Models.

Dr. Kutner’s lifetime contributions to research, teaching and mentoring are not only legendary, but they give integrity and energy to public health and to Emory. On April 5th, the Woodruff Health Sciences Center and the Rollins School of Public Health will celebrate Dr. Kutner’s distinguished career with a reception in the RSPH Klamon Room at 4 p.m.

RSVP to Nancy Sterk at nsterk@emory.edu.

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