Warren symposium follows legacy of geneticist giant

If we want to understand how the brain creates memories, and how genetic disorders distort the brain’s machinery, then the fragile X gene is an ideal place to start. That’s why the Stephen T. Warren Memorial Symposium, taking place November 28-29 at Emory, will be a significant event for those interested in neuroscience and genetics. Stephen T. Warren, 1953-2021 Warren, the founding chair of Emory’s Department of Human Genetics, led an international team that discovered Read more

Mutations in V-ATPase proton pump implicated in epilepsy syndrome

Why and how disrupting V-ATPase function leads to epilepsy, researchers are just starting to figure Read more

Tracing the start of COVID-19 in GA

At a time when COVID-19 appears to be receding in much of Georgia, it’s worth revisiting the start of the pandemic in early 2020. Emory virologist Anne Piantadosi and colleagues have a paper in Viral Evolution on the earliest SARS-CoV-2 genetic sequences detected in Georgia. Analyzing relationships between those virus sequences and samples from other states and countries can give us an idea about where the first COVID-19 infections in Georgia came from. We can draw Read more

Study: Regular aerobic exercise and prevention of drug abuse relapse

Exercise provides health benefits

Researchers at Emory University and the University of Georgia have received funding from the National Institutes of Health to study the neurobiological mechanisms for how regular aerobic exercise may prevent drug abuse relapse. The grant is for $1.9 million over the next five years.

David Weinshenker, PhD, associate professor of human genetics, Emory School of Medicine, is a co-principal investigator on the project.

David Weinshenker, PhD

“This research will provide new insight into how regular exercise may attenuate drug abuse in humans,” Weinshenker says. “More importantly, it may reveal a neural mechanism through which exercise may prevent the relapse into drug-seeking behavior.”

During the study, Weinshenker and UGA co-investigator Philip Holmes, professor of psychology in the Franklin College of Arts and Sciences, will measure exercise-induced increases of the galanin gene activity in the rat brain.

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Conference inspires medical volunteerism

Allen Dollar, MD, assistant professor of medicine (Division of Cardiology), Emory School of Medicine, and  Grady Chief of Cardiology, wanted to help those in developing countries long before he went to medical school. He’s donated his time and expertise in places like Cambodia, Vietnam, El Salvador and Sri Lanka, using his vacations to teach and heal. For the last decade, through Children’s Cross Connections, he’s held clinics and taught medical students in Ethiopia.

International Conference on Medical Volunteerism met at Emory in April

Dollar and nearly 200 others shared their experiences at a conference at Emory in April. The inaugural International Conference on Medical Volunteerism was hosted by the Emory School of Medicine and co-hosted by Morehouse School of Medicine, Mercer University School of Medicine, Medical College of Georgia, Philadelphia College of Osteopathic Medicine and the Medical University of South Carolina.

The conference aimed at inspiring and enabling volunteers, including how to establish a community clinic, how to advocate for disabled and homeless, cultural sensitivity and media relations.

Organizations from around the world were represented, among them Mercy Ships, Flying Doctors of America, Operation Safety Net, the Mayo and Cleveland clinics, Palestinian Children’s Relief Fund, Nurses for the Nations, Global HEED and Jewish Healthcare International.

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Visioning for the future of aging and health

Ted Johnson, MD, says the United States is not prepared to meet the care needs of the next wave of aging older adults. “The statistics nationally show that by the year 2030, the demographics of every U.S. state will be similar to that of Florida today. Another way of looking at that: the number of people age 65 and older in the state of Georgia will increase 100 percent by 2020. We’re facing a tremendous aging wave, and we don’t know how we’re going to meet the needs of that group.”

Ted Johnson, MD

Johnson is leading the Emory Center for Health in Aging, a program that addresses health care issues affecting the rapidly growing senior population in the United States through research, clinical care, community outreach and education.

Johnson also serves as director of the Division of Geriatrics and Gerontology, Department of Medicine, Emory University School of Medicine, and is associate director and Atlanta site director for the Birmingham/Atlanta VA Geriatric Research, Education, and Clinical Center.

Johnson says he is committed to a new vision of aging. His agenda for reaching that vision:

Target conditions associated with disability common in seniors: We need to target specific disease processes–Alzheimer’s, urinary/fecal incontinence, obesity, congestive heart failure–and develop breakthrough treatments and better predictive models so that we can understand what it is that makes people with these chronic conditions get out of control and currently, end up in nursing homes.

Build livable communities: We need to build communities that will sustain people as they age, and that means livable and walkable communities, with public transportation and access to stores and food. We need urban planning, as well as rural planning. Aging people shouldn’t lose their ability to live independently because they can no longer drive a car.

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Composting food waste at Emory hospitals

Wasted food is composted at Emory hospitals

Food service workers in Emory’s hospitals have always been conscientious about reducing waste, trying to walk the fine line between preparing too much food and too little.

But when new pilot programs in composting food waste began recently at Wesley Woods Geriatric Hosptial and then Emory University Hospital, staff were surprised to see how much waste piled up—and how much could be diverted from landfills or garbage disposals and converted into compost, some of which will return to Emory to enrich campus flower beds.

Food composting efforts such as these are some of the fruits of a sustainability task force established in health sciences by Executive Vice President for Health Affairs Fred Sanfilippo, MD, PhD.

Lynne Ometer

Director of Emory’s food and nutrition services Lynne Ometer, and her team, began connecting Emory’s hospitals with a waste-to-compost program already under way at Emory University.

As the smallest and most compact of the hospitals, Wesley Woods Geritric Hospital went first, focusing on “preconsumer” waste – scraps generated in food preparation or unusable food items left after serving, and on some “postconsumer” waste – food that has already been served to a patient.

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NIAID Director Fauci: link seasonal and pandemic flu preparedness

Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, delivered the keynote address Sunday, April 18, as part of a three-day conference on H1N1 Virus: The First Pandemic of the 21st Century, sponsored by the Emory-UGA Influenza Pathogenesis and Immunology Research Center.

One of the most important lessons from this past year’s pandemic, Fauci said, is the need to “connect the dots” between seasonal and pandemic influenza and not view them as two separate phenomena.

Fauci enthusiastically supports the CDC’s call for universal flu vaccination.

“Rather than trying to figure out one priority group over another,” Fauci said, “if we can get into a rhythm of getting most people vaccinated each year, we will have most of the population with some degree of immunity. We will get into a situation where we don’t need to go from a seasonal approach to a crisis approach.

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NIH director visits Emory, Atlanta Clinical & Translational Science Institute

David Stephens, MD, Jim Wagner, PhD, Earl Lewis, PhD, Francis Collins, MD, PhD

Dr. Francis Collins, director of the National Institutes of Health, and chief of staff Dr. Kathy Hudson, paid a daylong visit to Emory’s Woodruff Health Sciences Center, including Yerkes National Primate Research Center, and Morehouse School of Medicine on April 14.

The purpose of Collins’ visit was to view the activities of the Atlanta Clinical and Translational Science Institute, one of 46 national CTSAs funded by the NIH through the National Center for Research Resources (NCRR).  Collins also will visit CTSAs at Duke, UNC, and Vanderbilt in the future.

Collins asked that his visit focus on “how CTSAs are enabling science.” It was an opportunity for the ACTSI, a partnership among Emory, Morehouse School of Medicine, Georgia Institute of Technology and others, including Children’s Healthcare of Atlanta, Georgia Research Alliance, Georgia BIO, Kaiser Permanente, CDC, the Atlanta VA Medical Center and the Grady Health System, to showcase the unique contributions the ACTSI makes to enabling clinical and translational research.

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HER2-positive breast cancer treatment options studied

Emory oncologist Ruth O’Regan, MD, is leading a trial testing whether Afinitor can reverse resistance to Herceptin in metastatic HER2-positive breast cancer patients. As part of the trial, some patients been receiving a drug called Afinitor (everolimus) along with chemotherapy and Herceptin (trastuzumab).

Ruth O'Regan, MD

About 25 percent to 30 percent of breast cancers are HER2 -positive, which means they test positive for a protein called human epidermal growth factor receptor-2 (HER2). This protein promotes the growth of cancer cells, making HER2 -positive breast cancers more aggressive than other types.

They also tend to be less responsive to hormone treatment. That’s the bad news. The good news is that this type of cancer responds extremely well to Herceptin.

Herceptin specifically targets HER2 cells, killing them while sparing healthy cells, so side effects are minimal. Its effectiveness has made Herceptin the gold standard of treatment for HER2 -positive breast cancer.

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Medical volunteerism conference

A free weekend conference at Emory, beginning April 16 at 7 p.m., brings together health professionals and the general public to learn more about medical volunteerism. The event features keynote addresses, exhibits and brainstorming panel discussions on a variety of topics. Participants will be able to network with the general public, students, nurses and physicians representing all areas of health care.

The inaugural “International Conference on Medical Volunteerism” (ICMV) is hosted by the Emory School of Medicine and co-hosted by Morehouse School of Medicine, Mercer University School of Medicine, Medical College of Georgia, Philadelphia College of Osteopathic Medicine and the Medical University of South Carolina.

Conference organizers say they are offering a diverse array of events and presenters in hopes of inspiring more people to volunteer and create synergies among volunteer organizations and volunteers themselves.

“We want attendees to walk away with new, innovative ways and connections to help improve the overall health of the human race, particularly the underserved,” says Neil Shulman, MD, associate professor at Emory School of Medicine and chairman of the Conference Organizing Committee.

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Hold out your finger: Epidemiologist developing test for colon cancer risk

Years from now, physicians may be able to determine whether you’re at increased risk for colon cancer by drawing blood from the tip of your finger.

Emory University researchers are working to identify biomarkers to detect a person’s chances of developing colon cancer. Much like blood pressure and cholesterol tests can indicate heart disease risk, researchers here hope that some day the makeup of blood and urine will be able to tell who’s at risk for colorectal cancer, why they may be at risk and what they can do to reduce their risk.

Postdoctoral fellows Joy Owen and Veronika Fedirko examine samples in Robin Bostick’s lab at the Winship Cancer Institute of Emory University.

For now, the Emory study team is analyzing the rectal tissue samples of people with colon adenomatous polyps, non-cancerous growths considered precursors to colon cancer, and comparing them to rectal tissue samples from people who don’t have polyps. They’re also looking at whether the differences they detect in rectal tissue can also be found in blood or urine. Currently, no accepted tests exist to determine whether someone may be at risk for colon cancer.

“Most people would rather provide a blood or urine sample than get a rectal biopsy,” says Robin Bostick, MD, MPH, Rollins School of Public Health epidemiology professor and study principal investigator. Bostick is also a clinical faculty member at the Winship Cancer Institute at Emory and a Georgia Cancer Coalition Distinguished Cancer Scholar.

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Combined MR/PET imaging

On Thursday, April 8, Emory’s Center for Systems Imaging, directed by Department of Radiology Chair Carolyn Meltzer, MD, and the Atlanta Clinical & Translational Science Institute celebrated the launch of the CSI’s prototype MR/PET imaging scanner.

View of MR/PET

View of MR/PET scanner from front, with Ciprian Catana of MGH and Larry Byars of Siemens

The scanner is one of four world-wide and one of two in the United States, and permits simultaneous MR (magnetic resonance) and PET (positron emission tomography) imaging in human subjects. This provides the advantage of being able to combine the anatomical information from MR with the biochemical/metabolic information from PET. Potential applications include functional brain mapping and the study of neurodegenerative diseases, drug addiction and brain cancer.

Thursday’s event brought together leaders of the three other MR/PET programs in Boston, Jülich and Tübingen, the Siemens engineers who designed the device, and the Atlanta research community to explore the possibilities of the technology.

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