Zika virus blindfolds immune alarm cells

Important immune alarm cells — dendritic cells — are fighting Zika virus with an arm tied behind their backs, scientists from Emory Vaccine Center report.

Dendritic cells are “sentinel” cells that alert the rest of the immune system when they detect viral infection. When Zika virus infects them, it shuts down interferon signaling, one route for mustering the antiviral troops. However, another antiviral pathway called RIG-I-like receptor (RLR) signaling is left intact and could be a target for immunity-boosting therapies, the researchers say.

Mehul Suthar, PhD in the lab with graduate students Kendra Quicke and James Bowen

The findings were published on Feb. 2 in PLOS Pathogens.

Zika was known to disrupt interferon signaling, but Emory researchers have observed that it does so in ways that are distinct from other related flaviviruses, such as Dengue virus and West Nile virus. The findings give additional insight into how Zika virus is able to counter human immune defenses.

“This is the first demonstration of a flavivirus actively blocking translation of type I interferon, a critical set of innate immune signaling proteins,” says Mehul Suthar, PhD, assistant professor of pediatrics at Emory University School of Medicine and Emory Vaccine Center.

In addition, the researchers found that Zika blocks the phosphorylation of the immune regulatory proteins STAT1 and STAT2, which has not been previously reported.

The researchers studied a recently isolated Puerto Rican strain of Zika, as well as historic African and Asian strains. All of the tested Zika viruses blocked type I interferon signaling, suggesting a highly conserved mechanism amongst Zika viruses to inhibit dendritic cell antiviral responses.

Zika’s stealthy infection of dendritic cells resembles its effects on other fetal and placental cell types, including findings from the authors’ previous publication on placental macrophages.

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Posted on by Quinn Eastman in Immunology Leave a comment

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Quinn Eastman

Science Writer, Research Communications qeastma@emory.edu 404-727-7829 Office

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