Cancer research: souping up adoptive cell therapy

Several current clinical trials are testing CpG or related TLR9 agonists, but mostly in the context of delivering them as in vivo adjuvants. This is Read more

Report on first Omicron case detected in GA

The first Omicron case detected in Georgia probably became infected during a visit to Cape Town, South Read more

spermidine

Connections between starvation and immunological memory

Researchers at Emory have been revealing several connections between cells’ responses to starvation and immunological memory. The latest example of this is a paper in Nature Immunology from Rafi Ahmed’s lab, showing that the cellular process of autophagy (literally: self-consumption) is essential for forming and maintaining memory T cells.

This finding has some practical implications for vaccination and could point the way to additives that could boost vaccine effectiveness in elderly humans. Researchers at Oxford have demonstrated that autophagy is diminished in T cells from aged mice, and T cell responses could be boosted in older mice using the autophagy-inducing compound spermidine. Read more

Posted on by Quinn Eastman in Immunology Leave a comment