NINDS supporting Emory/UF work on myotonic dystrophy

NINDS grant will support collaboration between Gary Bassell and Eric Wang on myotonic Read more

Antios moving ahead with potential drug vs hepatitis B

Antios Therapeutics is moving ahead clinical studies of an antiviral drug aimed at hepatitis Read more

Traynelis lead researcher on CureGRIN/Chan Zuckerberg award

The CureGRIN Foundation works closely with Emory pharmacologist Stephen Traynelis, who has been investigating rare genetic disorders affecting NMDA Read more

ShiQin Xiong

Anti-aging tricks from dietary supplement seen in mice

Our recent news item on a Cell Reports paper from ShiQin Xiong and Wayne Alexander describes a connection between two important biological molecules: the exercise-induced transcription coactivator PGC1-alpha and the enzyme telomerase, sometimes described as a “fountain of youth” because telomeres protect the ends of chromosomes.

While the Emory researchers did not directly assess the effects of exercise in their experiments, their findings provide molecular clues to how exercise might slow the effects of aging or chronic disease in some cell types.

Xiong and Alexander found that the dietary supplement alpha lipoic acid (ALA) can stimulate telomerase, with positive effects in a mouse model of atherosclerosis. ALA is a sulfur-containing fatty acid used to treat diabetic neuropathy in Germany, and has previously been shown to combat atherosclerosis in animal models. The Emory authors’ main focus was on vascular smooth muscle cells and note that more study of ALA’s effects on other cell types is needed.

Below are four key references that may help you put the Cell Reports paper in context: Read more

Posted on by Quinn Eastman in Uncategorized Leave a comment