At a time when COVID-19 appears to be receding in much of Georgia, it’s worth revisiting the start of the pandemic in early 2020. Emory virologist Anne Piantadosi and colleagues have a paper in Viral Evolution on the earliest SARS-CoV-2 genetic sequences detected in Georgia.
Analyzing relationships between those virus sequences and samples from other states and countries can give us an idea about where the first COVID-19 infections in Georgia came from. We can draw Read more
Drug abuse researchers are using the social media site Reddit as a window into the experiences of people living with opioid addiction.
Abeed Sarker in Emory's Department of Biomedical Informatics has a paper in Clinical Toxicology focusing on the phenomenon of “precipitated withdrawal,” in collaboration with emergency medicine specialists from Penn, Rutgers and Mt Sinai.
Precipitated withdrawal is a more intense form of withdrawal that can occur when someone who was using opioids starts medication-assisted treatment Read more
The big news out of CROI (Conference on Retroviruses and Opportunistic Infections) was a report of a third person being cured of HIV infection, this time using umbilical cord blood for a hematopoetic stem cell transplant. Emory’s Carlos del Rio gave a nice overview of the achievement for NPR this morning.
As del Rio explains, the field of HIV cure research took off over the last decade after Timothy Brown, known as “the Berlin patient,” Read more
Consider this: Alzheimerâ€™s is a uniquely human disorder. But why? Why donâ€™t nonhuman primates, such as monkeys, get Alzheimerâ€™s disease. Monkeys form the senile plaques that are identical to the plaques found in humans. So do other animals.
â€œYet, despite the fact that nonhuman primates make this protein that we know is very important in the pathogenesis of Alzheimerâ€™s disease, they donâ€™t develop the full disease,â€ says Lary Walker, PhD. Walker is an associate professor at Yerkes National Primate Research Center.
â€œThey donâ€™t develop the tangles we associate with Alzheimerâ€™s disease, the neuronal loss, the shrinkage of the brain, and they donâ€™t get demented in the sense that humans do,â€ says Walker.
When our bodies make a protein, the protein tends to fold into a functional form. But when it comes to Alzheimerâ€™s disease, some proteins misfold, becoming sticky and then combining with one another. In their collective form, the proteins can then form plaques or tangles, the two types of lesions associated with Alzheimerâ€™s disease.
And for some unknown reason, people who have plaques usually go on to form tangles. But people who have tangles donâ€™t always go on to form plaques. No one is sure why. But thatâ€™s what researcher Walker wants to find out.
To listen to Walkerâ€™s own words about Alzheimerâ€™s disease, access Emoryâ€™s new Sound Science podcast.
This year’s riders traveled from Emory to Eatonton, Georgia, and back to Emory along with a volunteer crew.
Because of generous sponsorships, Action Cycling donates 100 percent of funds raised by participants to AIDS vaccine research. These unrestricted funds fill gaps that cannot be met by grant dollars alone.
A study published in the May 17, 2010, issue of the journal Pediatrics found that one type of pesticide commonly used on fruits and vegetables may be contributing to attention deficit hyperactivity disorder, or ADHD, in children.
The study measured the levels of pesticide byproducts in the urine of 1,139 children from across the United States. Children with the highest concentration of pesticides in their urine were more likely to have symptoms of ADHD.
Barr says while the study doesnâ€™t prove causality between pesticide exposures and ADHD, it does shed light on how even low level daily exposures to pesticides could potentially impact cognitive health.
â€œIt seems very plausible that low-level daily exposures to pesticides can produce some subtle effects like ADHD or other neurological delays,â€ she says.
Barr notes that additional research is needed to confirm a connection to pesticides and ADHD, but says there are tips for limiting your exposure to commonly used pesticides.
â€œWeâ€™ve done studies here at Emory and also at CDC that have indicated that if you use organic food or if you wash your food properly prior to preparation, you can reduce the levels of these metabolites in your urine.Â Eat as much organic produce as possible, or wash your fruits and vegetables very well and that likely could decrease the chances of your children developing ADHD,â€ says Barr.
Peking University administrators with Georgia Tech, Emory delegation
A recent trip to Peking University (PKU) by administrators from Georgia Tech and Emory included a formal signing ceremony for the joint Georgia Tech/Emory/PKU PhD program in biomedical engineering. Georgia Tech President Bud Peterson and Tech Engineering Dean Don Giddens made the trip along with Larry McIntire, chair of the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory and Cheng Zhu, BME associate chair of international programs.
The joint PhD program was first announced last February and began enrolling its first students last fall. Students apply to the program through either the Department of Biomedical Engineering at PKU or the Coulter Department at Georgia Tech and Emory. Primary classes and research take place on the studentâ€™s home campus, but students spend at least a year in classes and research on the secondary campus.
Young, who is world-renowned for his work on the role of neuropeptides in regulating social behavior, uses voles to investigate the neurobiological and genetic mechanisms underlying social behavior. Using the monogamous prairie vole (vs. the promiscuous meadow vole) as a model organism, Young and his research team identified the oxytocin and vasopressin receptors as key mediators of social bonding and attachment. In addition, they are examining the consequences of social bond disruption as a model of social loss-induced depression.
This work has important implications for developing novel treatment strategies for psychiatric disorders associated with social cognitive deficits, including autism spectrum disorders and schizophrenia.
Physicians and researchers are seeing a resurgence of micronutrient deficiencies in certain high-risk populations of children. But what exactly does that mean to those childrenâ€”right now and in the future?
For children who donâ€™t get enough micronutrients it means life-long problems, including decreased neurodevelopment and diminished cognitive abilities.
â€œMicronutrients are nutrients that are needed by the body in small quantities and are important for development, growth and sustaining life,â€ says Conrad Cole, MD, MPH, assistant professor of pediatrics in the Division of Pediatric Gastroenterology and Nutrition in Emory School of Medicine. â€œThatâ€™s why theyâ€™re called micronutrients, and the ones we commonly think about are iron, vitamin D, calcium and zinc because they all have significant importance.â€
To listen to Coleâ€™s own words about micronutrients, access Emory’s new Sound Science podcast.
An Emory transplant team, working with the UGA group, hopes to use this technology to develop pig islet cells as an alternative to human islets to treat patients with Type 1 diabetes. Type 1 diabetes usually occurs early in life and affects more than one million Americans who are unable to manufacture their own insulin because their pancreatic islets do not function.
Emory islet transplant team
The Emory Transplant Center has conducted clinical trials since 2003 transplanting human pancreatic islet cells into patients with Type I diabetes. Some of these patients have been able to give up insulin injections, either temporarily or permanently. Other sources of islets are needed for transplant though because of the large number of potential patients and because each transplant typically requires islets from several pancreases.
To create pigs using pluripotent stem cells, the UGA team injected new genes into pig bone marrow cells to reprogram the cells into functioning like embryonic stem cells. The resulting pluripotent cells were inserted into blastocysts (developing embryos), and the embryos were implanted into surrogate mothers. The resulting pigs had cells from the stem cell lines as well as the embryo donor in multiple tissue types.
The pluripotent stem cell process could allow researchers to make genetic changes to dampen or potentially eliminate the rejection of the pig islets by the human immune system.
Authors writing in the journal say that dietary interventions to lower blood cholesterol concentrations and to modify blood lipoprotein levels are the cornerstone of prevention and treatment plans for coronary heart disease.
Nuts are rich in plant proteins, fats (especially unsaturated fatty acids), dietary fiber, minerals, vitamins and other compounds, such as antioxidants and phytoesterols. The contents of nuts are a focus because of the potential to reduce coronary heart disease risk and to lower blood lipid – fat and cholesterol – levels.
While most of the calories provided from nuts come from fat, notes Williams, it is mostly unsaturated fats (mono and polyunsaturated), which have been shown to help lower elevated serum cholesterol, and to some extent triglyceride levels (via omega 3 fatty acids provided from walnuts).
“By integrating the fields of life sciences with engineering,” McIntire explains, “we can better understand the mechanisms of disease and develop new ways to diagnose and treat medical problems. We are working collaboratively in the fields of biomedical nanotechnology, predictive health, regenerative medicine, and health care robotics, among others.
Even with better immune suppressing drugs being developed for organ transplants, patients still require regular monitoring to prevent graft rejection. Kidney transplant recipients sometimes can be at risk even when standard blood tests for rejection appear stable.
To improve accuracy and avoid the need for frequent biopsies, several teams of transplant specialists are developing new urine tests for diagnosing acute organ rejection. These tests are non-invasive, could be administered often, and could identify immune events in real time.
At the American Transplant Congress this week in San Diego, Jennifer Jackson, MD, a nephrology fellow on the Emory kidney transplant team, presented research on a new urine-based test for the protein osteoprotegerin (OPG) and the chemokines CSCL9 and CXCL10.
Researchers found levels for all three markers elevated in patients experiencing acute rejection, but also in some patients whose grafts were supposedly â€œstable.â€ This smoldering inflammation could be responsible for chronic graft deterioration that goes undetected.