Head to head narcolepsy/hypersomnia study

At the sleep research meeting in San Antonio this year, there were signs of an impending pharmaceutical arms race in the realm of narcolepsy. The big fish in a small pond, Jazz Pharmaceuticals, was preparing to market its recently FDA-approved medication: Sunosi/solriamfetol. Startup Harmony Biosciences was close behind with pitolisant, already approved in Europe. On the horizon are experimental drugs designed to more precisely target the neuropeptide deficiency in people with classic narcolepsy type 1 Read more

Anti-inflammatory approach suppresses cancer metastasis in animal models

An anti-inflammatory drug called ketorolac, given before surgery, can promote long-term survival in animal models of cancer metastasis, a team of scientists has found. The research suggests that flanking chemotherapy with ketorolac or similar drugs -- an approach that is distinct from previous anti-inflammatory cancer prevention efforts -- can unleash anti-tumor immunity. The findings, published in Journal of Clinical Investigation, also provide a mechanistic explanation for the anti-metastatic effects of ketorolac, previously observed in human Read more

I3 Venture awards info

Emory is full of fledgling biomedical proto-companies. Some of them are actual corporations with employees, while others are ideas that need a push to get them to that point. Along with the companies highlighted by the Emory Biotech Consulting Club, Dean Sukhatme’s recent announcement of five I3 Venture research awards gives more examples of early stage research projects with commercial potential. This is the third round of the I3 awards; the first two were Wow! Read more

National Institute of Research Resources

NIH director visits Emory, Atlanta Clinical & Translational Science Institute

David Stephens, MD, Jim Wagner, PhD, Earl Lewis, PhD, Francis Collins, MD, PhD

Dr. Francis Collins, director of the National Institutes of Health, and chief of staff Dr. Kathy Hudson, paid a daylong visit to Emory’s Woodruff Health Sciences Center, including Yerkes National Primate Research Center, and Morehouse School of Medicine on April 14.

The purpose of Collins’ visit was to view the activities of the Atlanta Clinical and Translational Science Institute, one of 46 national CTSAs funded by the NIH through the National Center for Research Resources (NCRR).  Collins also will visit CTSAs at Duke, UNC, and Vanderbilt in the future.

Collins asked that his visit focus on “how CTSAs are enabling science.” It was an opportunity for the ACTSI, a partnership among Emory, Morehouse School of Medicine, Georgia Institute of Technology and others, including Children’s Healthcare of Atlanta, Georgia Research Alliance, Georgia BIO, Kaiser Permanente, CDC, the Atlanta VA Medical Center and the Grady Health System, to showcase the unique contributions the ACTSI makes to enabling clinical and translational research.

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