SARS-CoV-2 culture system using human airway cells

Journalist Roxanne Khamsi had an item in Wired highlighting how virologists studying SARS-CoV-2 and its relatives have relied on Vero cells, monkey kidney cells with deficient antiviral responses. Vero cells are easy to culture and infect with viruses, so they are a standard laboratory workhorse. Unfortunately, they may have given people the wrong idea about the controversial drug hydroxychloroquine, Khamsi writes. In contrast, Emory virologist Mehul Suthar’s team recently published a Journal of Virology paper on culturing Read more

Triple play in science communication

We are highlighting Emory BCDB graduate student Emma D’Agostino, who is a rare triple play in the realm of science communication. Emma has her own blog, where she talks about what it’s like to have cystic fibrosis. Recent posts have discussed the science of the disease and how she makes complicated treatment decisions together with her doctors. She’s an advisor to the Cystic Fibrosis Foundation on patient safety, communicating research and including the CF community Read more

Deep brain stimulation for narcolepsy: proof of concept in mouse model

Emory neurosurgeon Jon Willie and colleagues recently published a paper on deep brain stimulation in a mouse model of narcolepsy with cataplexy. Nobody has ever tried treating narcolepsy in humans with deep brain stimulation (DBS), and the approach is still at the “proof of concept” stage, Willie says. People with the “classic” type 1 form of narcolepsy have persistent daytime sleepiness and disrupted nighttime sleep, along with cataplexy (a loss of muscle tone in response Read more

National Institute of Environmental Health Sciences

Zika immunology from returned travelers

At the American Association for the Advancement of Science meeting in Boston last weekend, Emory Vaccine Center researcher Mark Mulligan presented some limited findings on immune responses in Zika-infected humans, who were returned US travelers or expatriates.

The results were intriguing, despite the small number of study participants: five, two of whom were pregnant. Detailed information has not been available about immune responses against Zika in humans, especially T cell responses.

Highlights from Mulligan’s abstract:

*All five seemed to have a hole in their immune systems – functional antiviral “killer” CD8 T cells were rare, despite activation of CD8 T cells in general and strong responses from other cell types.

*Cross-reactive immune responses, based on previous exposure to dengue and/or yellow fever vaccine, may have blunted Zika’s peak.

*”Even with prolonged maternal viremia, both pregnancies resulted in live births of apparently healthy babies.” Read more

Posted on by Quinn Eastman in Immunology Leave a comment

Improving measurement of pesticides in breast milk

Little is known about the exposure of infants to pesticides, despite their vulnerability and evidence of widespread dietary exposure among older children and adults. A study led by Emory Rollins School of Public Health researchers P. Barry Ryan, PhD, and Anne Riederer, ScD, seeks to improve methods for measuring pesticides in breast milk and infant formula.

“We really don’t know about how babies are exposed to pesticides in their everyday life,” says Riederer, assistant research professor, Department of Environmental and Occupational Health. “There are very few published studies on this topic, and we’d like to be one of the groups that actually publishes an analytical method that can be used by researchers in any country to be able to detect these different types of pesticides in breast milk.”

Although the breast milk method will be pilot tested on samples collected from a birth cohort in Thailand, it will have broad applications for the U.S. population. Because these pesticides are widely distributed in the food supply, all U.S. infants are potentially exposed.

Read more

Posted on by admin in Uncategorized Leave a comment