Emory BCDB graduate student Emma D’Agostino
We are highlighting Emory BCDB graduate student Emma D’Agostino, who is a rare triple play in the realm of science communication.
Emma has her own blog, where she talks about what it’s like to have cystic fibrosis. Recent posts have discussed the science of the disease and how she makes complicated treatment decisions together with her doctors. She’s an advisor to the Cystic Fibrosis Foundation on patient safety, communicating research and including the CF community in the research process. She’s also working in biochemist Eric Ortlund’s lab on nuclear receptors in the liver:drug targets for the treatment of diabetes and intestinal diseases.
The triple play is this — on her blog, Emma has discussed how she has to deal with antibiotic resistance. Emory Antibiotic Resistance Center director David Weiss’ lab has published a lot on colistin: how it’s a last-resort drug because of side effects, and how difficult-to-detect resistance to it is spreading. Emma has some personal experience with colistin that for me, brought the issue closer. Read more
For podcast listeners in the Emory biomedical research community, Behind the Microscope is a must-follow. It is produced by four students in Emory’s MD/PhD program: Carey Jansen, Joe Behnke, Michael Sayegh and Bejan Saeedi. They’re focused on career issues such as mentorship and grant strategy rather than the science itself (thus, complementary to Lab Land).
In their list of interviewees so far, they lean toward their fellow “double docs.” Since starting off in October, they’ve talked with Anita Corbett, Brian Robinson, Sean Stowell, Stefi Barbian and Steven Sloan (MD/PhDs underlined). Here are the Apple and Google podcast listings; episodes are also available on platforms such as Anchor.fm.
Editor’s note: guest post from Neuroscience graduate student Erica Landis.
Neuroscience graduate student Erica Landis
Evidence is increasing that lack of reproducibility, whatever the cause, is a systemic problem in biomedical science. While institutions like the NIH and concerned journal editors are making efforts to implement more stringent requirements for rigorous and reproducible research, scientists themselves must make conscious efforts to avoid common pitfalls of scientific research. Here at Emory, several scientists are making greater efforts to push forward to improve scientific research and combat what is being called “the reproducibility crisis.”
In 2012, C. Glenn Begley, then a scientist with the pharmaceutical company Amgen, published a commentary in Nature on his growing concern for the reproducibility of preclinical research. Begley and his colleagues had attempted to replicate 53 published studies they identified as relevant to their own research into potential pharmaceuticals. They found that only 6 of the 53 publications could be replicated; even with help from the original authors. Similar studies have consistently found that greater than 50 percent of published studies could not be replicated. This sparked a period of great concern and questioning for scientists. It seemed to Begley and others that experimenter bias, carelessness, poor understanding of statistics, and the career-dependent scramble to publish contributes to a misuse of the scientific method. These factors contribute to what is now called the reproducibility crisis. In April 2017, Richard Harris published Rigor Mortis, a survey of the problem in preclinical research, which has kept the conversation going and left many wondering what the best solution to these issues could be. To combat the reproducibility crisis, Harris argues that funding agencies, journal editors and reviewers, research institutions, and scientists themselves all have a role to play.
Lab Land’s editor enjoyed talking with several students about their work at the GDBBS Student Research Symposium last week. Neurons dominateÂ the three contest-winning images. The Integrated Cellular Imaging coreÂ facilityÂ judged the winners. From left to right:
1st Place: Stephanie Pollitt,Â Neuroscience
2nd Place: Amanda York,Â Biochemistry, Cell and Developmental Biology
3rd Place: Jadiel Wasson, Biochemistry, Cell and Developmental Biology
Larger versions and explanations below.