Anti-inflammatory approach suppresses cancer metastasis in animal models

An anti-inflammatory drug called ketorolac, given before surgery, can promote long-term survival in animal models of cancer metastasis, a team of scientists has found. The research suggests that flanking chemotherapy with ketorolac or similar drugs -- an approach that is distinct from previous anti-inflammatory cancer prevention efforts -- can unleash anti-tumor immunity. The findings, published in Journal of Clinical Investigation, also provide a mechanistic explanation for the anti-metastatic effects of ketorolac, previously observed in human Read more

I3 Venture awards info

Emory is full of fledgling biomedical proto-companies. Some of them are actual corporations with employees, while others are ideas that need a push to get them to that point. Along with the companies highlighted by the Emory Biotech Consulting Club, Dean Sukhatme’s recent announcement of five I3 Venture research awards gives more examples of early stage research projects with commercial potential. This is the third round of the I3 awards; the first two were Wow! Read more

Take heart, Goldilocks -- and get more sleep

Sleeping too little or too much increases the risk of cardiovascular events and death in those with coronary artery disease, according to a new paper from Emory Clinical Cardiovascular Research Institute. Others have observed a similar U-shaped risk curve in the general population, with respect to sleep duration. The new study, published in American Journal of Cardiology, extends the finding to people who were being evaluated for coronary artery disease. Arshed Quyyumi, MD and colleagues analyzed Read more

kinase

Tangled up with tau

Pathologist Keqiang Ye and his colleagues have identified a new potential drug target in Alzheimer’s disease. It’s called SRPK2 (serine-arginine protein kinase 2).

Keqiang Ye, PhD

Depleting this enzyme from the brain using genetic engineering tools alleviates cognitive impairment in an animal model of Alzheimer’s. The result suggests that drugs Cheap Oakleys that target this enzyme could be valuable in the treatment of Alzheimer’s, although additional studies on human brain samples are necessary to fully confirm the findings, Ye says.

The results were published Tuesday in Journal of Neuroscience. The first author is postdoctoral fellow Yi Hong.

Hong and colleagues found that SRPK2 has elevated activity in a mouse model of Alzheimer’s. It acts on tau, one of the two major toxic clumpy proteins in Alzheimer’s. (beta-amyloid is outside the cell and forms plaques, tau is inside and forms tangles). Previous research on SRPK2 indicated that it had something to do with RNA splicing, so its “entanglement” with tau is a surprise.

Posted on by Quinn Eastman in Neuro Leave a comment