Immune outposts inside tumors predict post-surgery outcomes

The immune system establishes “forward operating bases”, or lymph node-like structures, inside the tumors of some patients with kidney and other urologic Read more

Hedgehog pathway outside cilia (with CBD bonus)

The Hedgehog pathway has roles in both specifying what embryonic cells will become and in guiding growing neural Read more

Tracking how steroid hormone receptor proteins evolved

When thinking about the evolution of female and male, consider that the first steroid receptor proteins, which emerged about 550 million years ago, were responsive to estrogen. The ancestor of other steroid hormone receptors, responsive to hormones such as testosterone, progesterone and cortisol, emerged many millions of years later. Biochemist Eric Ortlund and colleagues have a new paper in Structure that reconstructs how interactions of steroid receptor proteins evolved over time. This is a complex Read more

Jordan Kempker

Threshold for long-term marijuana effects on lung function

Intuition may suggest that smoke is bad for the lungs, whether it comes from a campfire or from tobacco or marijuana. A practical question is: how bad is an occasional joint, compared with some background level of air pollution and the lungs’ ability to cope?

Since a few states have been loosening restrictions on marijuana, a group of Emory pulmonologists – Jordan Kempker, Eric Honig, and Greg Martin — decided to look at the long-term effects of marijuana smoking on lung function. Their findings, published in the Annals of the American Thoracic Society (PDF), have already attracted some attention. Read more

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