Brain organoid model shows molecular signs of Alzheimer’s before birth

In a model of human fetal brain development, Emory researchers can see perturbations of epigenetic markers in cells derived from people with familial early-onset Alzheimer’s disease, which takes decades to appear. This suggests that in people who inherit mutations linked to early-onset Alzheimer’s, it would be possible to detect molecular changes in their brains before birth. The results were published in the journal Cell Reports. “The beauty of using organoids is that they allow us to Read more

The earliest spot for Alzheimer's blues

How the most common genetic risk factor in AD interacts with the earliest site of neurodegeneration Read more

Make ‘em fight: redirecting neutrophils in CF

Why do people with cystic fibrosis (CF) have such trouble with lung infections? The conventional view is that people with CF are at greater risk for lung infections because thick, sticky mucus builds up in their lungs, allowing bacteria to thrive. CF is caused by a mutation that affects the composition of the mucus. Rabindra Tirouvanziam, an immunologist at Emory, says a better question is: what type of cell is supposed to be fighting the Read more

happiness

Some thoughts on the pursuit of happiness

Corey Keyes, PhD

What does it truly mean to be in good mental health? How are good mental health and mental illness connected? That is, does being in good mental health simply mean the absence of mental illness, or is there more to it than that? And how do people achieve a healthy state of both body and mind?

These are some of the complex questions Emory researchers brought to the fore in a discussion over lunch last month.

Speaker Corey Keyes, an Emory sociologist, made clear the absence of illness does not necessarily mean the presence of health. He noted that the ancient Greeks batted around the subject of mental health, specifically, happiness. Some championed emotions and pleasures as a path to happiness, others tranquility, freedom and reflection. Read more

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