FMT microbial transplant for C diff gaining acceptance

The Infectious Diseases Society of America issued new guidelines for fighting C diff that include FMT (fecal microbiota Read more

Give a zap to Emory brain research for #STATMadness

Vote for Emory neuroscience research next week as part of Read more

Nox-ious link to cancer Warburg effect

Invitation from a talk by San Martin recently gave in Read more

genome databases

More on NMDA receptor variants + epilepsy/ID

NMDA receptors are complex electrochemical machines, important for signaling between brain cells. Rare mutations in the corresponding genes cause epilepsy and intellectual disability.

Pre-M1 helices in multi-subunit NMDA receptor. Adapted from Ogden et al PLOS Genetics (2017).

In Emory’s Department of Pharmacology, the Traynelis and Yuan labs have been harvesting the vast amounts of information now available from public genome databases, to better understand how changes in the NMDA receptor genes relate to function. (Take a “deeper dive” into their November 2016 publication on this topic here.)

Their recent paper in PLOS Genetics focuses on a particular region in the NMDA receptor, called the pre-M1 helix (see figure). It also includes experiments on whether drugs now used for Alzheimer’s disease, such as memantine, could be repurposed to have beneficial effects for patients with certain mutations. The in vitro data reported here could inform clinical use. Read more

Posted on by Quinn Eastman in Neuro Leave a comment