The blue spot: where seeds of destruction begin

Learn more about the locus coeruleus, a "canary in the coal Read more

Complexity of NMDA receptor drug discovery target revealed

GluN2C heterotrimer dominant in cerebellum + thalamus -- possibly important target for Read more

Measuring sleepiness: alternatives to five naps

If the MSLT is unsatisfactory, what should replace or supplement Read more

electrophysiology

NMDA receptors: triple-quadruple axel

NMDA receptors are saddled with an unwieldy name, but they are some of the most important* signaling molecules in the brain, both for learning and memory and in neurological and psychiatric diseases.

Kasper Hansen, a postdoc from Stephen Traynelis’ lab who is establishing his own at the University of Montana, is lead author on a recent paper in Neuron, which could spur research on NMDA receptors’ pharmacological properties.

The NMDA receptors in the brain are actually mix-and-match assemblies of four subunits, and most of the time in the brain, three different proteins come together to make one receptor, the authors explain. In the laboratory, it has been easier to study simpler, more homogenous, but also more artificial constructs. Hansen and his colleagues developed a way to build replicas of the more complicated NMDA receptors found in the brain and probe their distinct responses to drugs. Read more

Posted on by Quinn Eastman in Neuro Leave a comment