Part of the new Winship magazine feature on prostate cancer focuses on a PET imaging probe called FACBC, which wasÂ developed by radiologists at Emory. 18F-FACBC (anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid, also called “fluciclovine”)Â has a lengthening track record in detecting recurrent prostate cancer.
Usually in PET imaging, radioactive glucose is injected into the body, and since cancer cells have a sweet tooth, they take up a lot of the radioactive tracer. But plenty of the tracer also appears in the urine, complicating prostate cancer detection efforts, since the prostate is so close to the bladder. In contrast, FACBCÂ is readily taken up by prostate cancer cells, but doesnâ€™t appear as much in urine.
Because of space considerations, we did not include David Schuster’s description of how FACBC’s utility in prostate was first discovered.Â Several years ago, heÂ and Mark Goodman had begun investigating the probe’s potential in imaging brain tumors and kidney tumors, and used it withÂ a patient with a large renal mass and many enlarged lymph nodes, as described in the radiology newsletter Aunt Minnie. Read more