The blue spot: where seeds of destruction begin

Learn more about the locus coeruleus, a "canary in the coal Read more

Complexity of NMDA receptor drug discovery target revealed

GluN2C heterotrimer dominant in cerebellum + thalamus -- possibly important target for Read more

Measuring sleepiness: alternatives to five naps

If the MSLT is unsatisfactory, what should replace or supplement Read more

6GPD

Potential anticancer drugs from humble sources

Jing Chen and colleagues at Winship Cancer Institute recently published a paper in Molecular Cell. Most of the paper deals with a metabolic enzyme, 6PGD (6-phosphogluconate dehydrogenase), and how it is more active in cancer cells.

Rhubarb_Flower

Rheum palmatum/Chinese rhubarb/da-huang

Tucked in at the end is a note that an inhibitor of 6GPD with an odd name, physcion, has anticancer activity in Chen’s team’s hands. Physcion, also known as parietin, is an orange-yellow pigment extractable from lichens and Chinese rhubarb that has been employed as an anti-mildew agent.

Probing cancer cells’ warped metabolism is a promising approach, for both drug discovery and finding effective ways to combine existing drugs, because of the Warburg effect: cancer cells’ tendency to suck up lots of sugar and use it in energy-inefficient ways. Read more

Posted on by Quinn Eastman in Cancer 1 Comment