Search Results for: keqiang

Tug of war between Parkinson’s protein and growth factors

September 19th, 2017 (No Comments)

A “tug of war” situation exists between Parkinson’s provocateur protein alpha-synuclein and the growth factor BDNF.

Drug discovery: Alzheimer’s and Parkinson’s spurred by same enzyme

July 12th, 2017 (No Comments)

One enzyme processes three notorious proteins: amyloid, tau *and* alpha-synuclein.

Amyloid vs tau? With this AD target, no need to choose

May 16th, 2017 (No Comments)

Alzheimer’s drug discovery paper from Emory pathologist Keqiang Ye. In mice, inhibiting AEP hits two targets (amyloid and tau) with one shot.

Parkinson’s disease: hold the AMPs

February 3rd, 2017 (No Comments)

Discussion of AMP kinase in Parkinson’s disease.

Manipulating motivation in mice

April 20th, 2016 (No Comments)

In humans, the medial orbitofrontal cortex (mOFC) is thought to be important for determining the value of a perceived reward. Through manipulation of a growth factor in the mOFC, Emory scientists were able to modulate a mouse’s tendency to persist in reward seeking. Image from O’Doherty et al, PLOS Biology (2006).

The secrets of a new Alzheimer’s secretase

December 3rd, 2015 (No Comments)

The current paper makes asparagine endopeptidase a potential Alzheimer’s drug target that is involved in the accumulation of *two* of the disease’s troublemaker proteins, tau and beta-amyloid. Hence the shiny new name: delta-secretase.

Are TrkB agonists ready for translation into the clinic?

March 12th, 2015 (No Comments)

7,8-dihydroxyflavone can be found in plants such as Godmania aescufolia, and has positive effects in animal models of several neurological diseases.

A crystal ball for Lab Land: Top 5 topics in 2015

January 2nd, 2015 (No Comments)

1. Alzheimer’s 2. Ebola 3. Hypersomnia 4. Microbiome/antibiotic resistance 5. Endovascular stroke

Acidity of aging leads to new Alzheimer’s drug target

November 10th, 2014 (No Comments)

Acidic conditions activate an enzyme (AEP) that snips tau, which forms neurofibrillary tangles in AD

Explainer: the locus coeruleus

October 29th, 2014 (No Comments)

Critical early site of neurodegeneration